2574-34-7

Upstream product

• 22965-98-6 4-(dimethylamino)chalcone 
• 100-63-0 phenylhydrazine 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 1030-27-9 4-dimethylamino-chalcone 
• 58122-02-4 3-(4-(dimethylamino)phenyl)-1-phenylpropan-1-one 
• 98-86-2 acetophenone 
• 59-88-1 phenylhydrazine hydrochloride 
• 1681-94-3 4-dimethylaminochalcone 

Downstream Products

• 28711-00-4 5-(4-dimethylaminophenyl)-1,3-diphenylpyrazole 

Relevant academic research and scientific papers

An eco-friendly synthesis of 2-pyrazoline derivatives catalysed by CeCl 3· 7 H 2O

Abstract: 1,3,5-triaryl-2-pyrazoline derivatives were synthesised by a condensation reaction between chalcones and phenyl hydrazine using cerium chloride heptahydrate as a catalyst. All these reactions were carried out in ethyl lactate (70%) as a green solvent. Easy and efficient work up, recyclability of solvent and catalyst are the key merits of this protocol. Graphical Abstract:: SYNOPSIS A facile protocol for the synthesis of 1,3,5-triaryl-2-pyrazolines is described. The solvent ethyl lactate, obtained from renewable sources, is biodegradable. The catalyst CeCl 3· 7 H 2O is a water-tolerant Lewis acid with low toxicity. Easy and clean work up, recyclable solvent and catalyst are merits of the protocol. The reaction works well for all systems giving good yields of the desired products.[Figure not available: see fulltext.].

1,3,5-Triarylpyrazolines - PH-driven off-on-off molecular logic devices based on a "receptor1-fluorophore-spacer-receptor2" format with internal charge transfer (ICT) and photoinduced electron transfer (PET) mechanisms

The excited state photophysical properties of the 1,3,5-triarylpyrazolines 1-4 were studied in methanol and 1:1 (ν/ν) methanol-water, as well as 1:4 (ν/ν) methanol-water and water by fluorescence spectroscopy. The molecules 2-4 incorporate a "receptorsub

Synthesis of some pyrazolone derivatives and evaluation of its antibacterial and cytotoxic activity

A series of novel pyrazolone derivative were synthesized by two different schemes (scheme-1 by the reaction of phenyl hydrazine and ethyl acetoacetate with substituted benzaldehydes PYR-1 to PYR-4) and (by the reaction of synthesized chalcone with phenyl hydrazine PYR-5) and characterised with its physical parameters (M.P, colour, %yield, solubility etc.). The entire synthesized compound was tested for their antimicrobial activity against Grampositive and Gram-negative strains of bacteria and brimeshrimp bioassay was conducted for evaluation of cytotoxic activity The Investigation of antimicrobial screening data revealed that most of the tested compounds showed moderate to good antimicrobial activity. And cytotoxicity activity of compounds was also found to be satisfactory.

Differential tuning of the electron transfer parameters in 1,3,5-triarylpyrazolines: A rational design approach for optimizing the contrast ratio of fluorescent probes

A large class of cation-responsive fluorescent sensors utilizes a donor-spacer-acceptor (D-A) molecular framework that can modulate the fluorescence emission intensity through a fast photoinduced intramolecular electron transfer (PET) process. The emissio

Synthesis of some new bioactive 1-N-subtituted 3,5-diaryl-2-pyrazolines

A group of four series (A-D) of 22 new bioactive 1-N-acid substituted 3, 5-diphenyl-2-pyrazolines were synthesized by cyclization of variably substituted chalcones and simple or substituted phenyl hydrazine and / or semicarbazide, using acetic acid as a s

A modified and convenient method for the preparation of N-phenylpyrazoline derivatives

Ten new N-phenylpyrazoline derivatives have been synthesized in high yields by condensation of chalcones with phenylhydrazine in the presence of potassium carbonate in reflux conditions. The workup is simple and involves treatment with ice-cold water. As compared with the previous method a considerable increase in the reaction rate with better yields has been observed.

Synthesis and antidepressant activity of some 1,3,5-triphenyl-2-pyrazolines and 3-(2″-hydroxy naphthalen-1″-yl)-1,5-diphenyl-2-pyrazolines

Five new 1,3,5-triphenyl-2-pyrazolines were synthesised by reacting 1,3-diphenyl-2-propene-1-one with phenyl hydrazine hydrochloride and another five new 3-(2″-hydroxy naphthalen-1″-yl)-1,5-diphenyl-2-pyrazolines were synthesised by reacting 1-(2′-hydroxy

REACTION OF SINGLET OXYGEN WITH 2-PYRAZOLINE: IMPLICATION FOR CATION RADICAL - SUPEROXIDE ION PAIR INTERMEDIATE

Kinetic studies on photosensitized oxygenation of 1,3,5-triaryl-2-pyrazolines show that an electron-transfer from the pyrazoline to singlet oxygen may take place to give a cation radical and superoxide ion pair.The reaction of pyrazoline cation radicals with superoxide ion shows the same product distribution with singlet oxygenation.