25770-52-9

Basic information

• Product Name: 2-AMINOQUINOLINE-P-TOLUENESULFONAMIDE
• Synonyms: 2-AMINOQUINOLINE-P-TOLUENESULFONAMIDE;4-Methyl-N-(quinolin-2-yl)benzenesulfonamide;Benzenesulfonamide,4-methyl-N-2-quinolinyl-
• CAS NO: 25770-52-9
• Molecular Formula: C₁₆H₁₄N₂O₂S
• Molecular Weight: 298.365
• Mol File: 25770-52-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 492.1±47.0 °C(Predicted)
• Appearance: /
• Density: 1.342±0.06 g/cm3 (20 ºC 760 Torr)
• PKA: 7.31±0.30(Predicted)
• CAS DataBase Reference: 2-AMINOQUINOLINE-P-TOLUENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINOQUINOLINE-P-TOLUENESULFONAMIDE(25770-52-9)
• EPA Substance Registry System: 2-AMINOQUINOLINE-P-TOLUENESULFONAMIDE(25770-52-9)

Safety Data

• Hazardous Substances Data: 25770-52-9(Hazardous Substances Data)

Usage

General Description

2-AMINOQUINOLINE-P-TOLUENESULFONAMIDE, also known simply as 2AQTSA, is a chemical compound with potential antitumor and antiproliferative properties. It is a derivative of 2-aminoquinoline and p-toluenesulfonamide, and has shown promise in inhibiting the growth of various cancer cell lines. It is believed that 2AQTSA works by interfering with the function of the enzyme carbonic anhydrase IX, which is overexpressed in many types of cancer and is associated with tumor progression and poor prognosis. Research into 2AQTSA is ongoing, with the hope that it may eventually be developed into a new therapeutic agent for the treatment of cancer.

Upstream product

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Relevant articles and documents

Intermolecular Amidation of Quinoline N-Oxides with Arylsulfonamides under Metal-Free Conditions

An efficient method for the synthesis of N-(quinolin-2-yl)sulfonamides is described. The intermolecular amidation of quinoline N-oxides with sulfonamides proceeded smoothly in the presence of PhI(OAc)2 and PPh3 to afford N-(quinolin-

Tandem Cu-catalyzed ketenimine formation and intramolecular nucleophile capture: Synthesis of 1,2-dihydro-2-iminoquinolines from 1-(o-acetamidophenyl) propargyl alcohols

The copper-catalyzed ketenimine formation reaction of 1-(o-acetamidophenyl) propargyl alcohols with various sulfonyl azides is found to undergo a concomitant intramolecular nucleophile attack to generate 1,2-dihydro-2- iminoquinolines after aromatization (via elimination of acetyl and hydroxy groups) and tautomerization. The reaction produces 4-substituted and 3,4-unsubstituted title compounds in moderate to good yields under mild reaction conditions.