25770-52-9

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINOQUINOLINE-P-TOLUENESULFONAMIDE is used as a potential therapeutic agent for the treatment of cancer. It is believed to inhibit the growth of various cancer cell lines by interfering with the function of the enzyme carbonic anhydrase IX, which is overexpressed in many types of cancer and is associated with tumor progression and poor prognosis. Ongoing research aims to develop 2AQTSA into a new treatment option for cancer patients.

Upstream product

• 1613-37-2 Quinoline N-oxide 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 13493-47-5 N-(2-formylphenyl)acetamide 
• 941-55-9 4-toluenesulfonyl azide 
• 148842-98-2 N-[2-(1-hydroxyprop-2-yn-1-yl)phenyl]acetamide 
• 91-22-5 quinoline 
• 70-55-3 toluene-4-sulfonamide 
• 2005-43-8 2-bromoquinoline 

Relevant academic research and scientific papers

Intermolecular Amidation of Quinoline N-Oxides with Arylsulfonamides under Metal-Free Conditions

An efficient method for the synthesis of N-(quinolin-2-yl)sulfonamides is described. The intermolecular amidation of quinoline N-oxides with sulfonamides proceeded smoothly in the presence of PhI(OAc)2 and PPh3 to afford N-(quinolin-

A N - 2 - quinoline-based aryl sulfonamide compound preparation method

The invention belongs to the technical field of fine chemical engineering, and discloses a preparation method of N-2-quinolyl aryl sulfonamide compounds. The preparation method can be used for synthesizing a series of N-2-quinolyl aryl sulfonamide compounds from aryl sulfonamide and derivative of quinoline N-oxide by carrying out a heating reaction in an organic solvent with a trivalent iodine compound serving as an oxidant and triarylphosphine compounds functioning as additives. The invention mainly aims at providing a synthesis method of the N-2-quinolyl aryl sulfonamide compounds. The method is simple and efficient, high in atom economy and environment-friendly; the method has the advantages of being simple in method step, easy in obtaining of raw materials, high in atom economy, environment-friendly and the like. The N-2-quinolyl aryl sulfonamide, as an important skeleton structure, can be widely applied to the medicine synthesis field, and has high use value and social and economic benefits.

Tandem Cu-catalyzed ketenimine formation and intramolecular nucleophile capture: Synthesis of 1,2-dihydro-2-iminoquinolines from 1-(o-acetamidophenyl) propargyl alcohols

The copper-catalyzed ketenimine formation reaction of 1-(o-acetamidophenyl) propargyl alcohols with various sulfonyl azides is found to undergo a concomitant intramolecular nucleophile attack to generate 1,2-dihydro-2- iminoquinolines after aromatization (via elimination of acetyl and hydroxy groups) and tautomerization. The reaction produces 4-substituted and 3,4-unsubstituted title compounds in moderate to good yields under mild reaction conditions.

Copper-mediated n-heteroarylation of primary sulfonamides: Synthesis of mono-n-heteroaryl sulfonamides

"Figure Presented" We describe the coupling of primary sulfonamides and various halogenated heterocyclic cores, with an emphasis on 2-heteroaryl halides, via copper catalysis. These studies enabled the synthesis of many new mono-N-heteroaryl sulfonamides.