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25775-03-5

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25775-03-5 Usage

General Description

2-(1H-Pyrazol-1-yl)benzonitrile is a chemical compound with the molecular formula C11H7N3. It is classified as a pyrazole derivative, containing a pyrazole ring and a benzonitrile group. 2-(1H-PYRAZOL-1-YL)BENZONITRILE has potential applications in the field of organic synthesis, medicinal chemistry, and material science. It may be used as a building block for the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. Additionally, it may exhibit biological activity and could be investigated for its potential as a drug candidate or as a chemical probe in biological research. Further research and development of 2-(1H-Pyrazol-1-yl)benzonitrile may lead to new applications and discoveries in the field of chemistry and biochemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 25775-03-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,7,7 and 5 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 25775-03:
(7*2)+(6*5)+(5*7)+(4*7)+(3*5)+(2*0)+(1*3)=125
125 % 10 = 5
So 25775-03-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H7N3/c11-8-9-4-1-2-5-10(9)13-7-3-6-12-13/h1-7H

25775-03-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-pyrazol-1-ylbenzonitrile

1.2 Other means of identification

Product number -
Other names 2-pyrazolylbenzenecarbonitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:25775-03-5 SDS

25775-03-5Relevant articles and documents

Design of an Electron-Withdrawing Benzonitrile Ligand for Ni-Catalyzed Cross-Coupling Involving Tertiary Nucleophiles

Edjoc, Racquel K.,Mills, L. Reginald,Rousseaux, Sophie A. L.

, p. 10422 - 10428 (2021/07/26)

The design of new ligands for cross-coupling is essential for developing new catalytic reactions that access valuable products such as pharmaceuticals. In this report, we exploit the reactivity of nitrile-containing additives in Ni catalysis to design a benzonitrile-containing ligand for cross-coupling involving tertiary nucleophiles. Kinetic and Hammett studies are used to elucidate the role of the optimized ligand, which demonstrate that the benzonitrile moiety acts as an electron-acceptor to promote reductive elimination over β-hydride elimination and stabilize low-valent Ni. With these conditions, a protocol for decyanation-metalation and Ni-catalyzed arylation is conducted, enabling access to quaternary α-arylnitriles from disubstituted malononitriles.

PYRAZOLYL COMPOUNDS AND METHODS OF USE THEREOF

-

Paragraph 0312-0317, (2020/05/14)

Compounds having activity as chemotherapeutic agents are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, stereoisomer, isotopic form or prodrug thereof, wherein R1a, R1b, R1c, R1d, L, and are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods for treating cancer (e.g., hematological cancers) are also provided.

Rhodium(iii)-catalyzed aromatic C-H cyanation with dimethylmalononitrile as a cyanating agent

Li, He,Zhang, Sheng,Yu, Xiaoqiang,Feng, Xiujuan,Yamamoto, Yoshinori,Bao, Ming

supporting information, p. 1209 - 1212 (2019/01/30)

A rhodium-catalyzed aromatic C-H bond direct cyanation with safe, bench-stable, and commercially available dimethylmalononitrile as the cyanating agent has been successfully developed by using copper oxide as a promotor. Pyridine, quinoline, pyrimidine and pyrazole were used as the directing group in this type of C-H bond direct cyanation reaction.

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