25782-57-4

Basic information

• Product Name: 4-Amino-α-phenylbenzyl alcohol
• Synonyms: 4-Amino-α-phenylbenzyl alcohol
• CAS NO: 25782-57-4
• Molecular Formula: C₁₃H₁₃NO
• Molecular Weight: 199.24842
• Mol File: 25782-57-4.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 393.8°C at 760 mmHg
• Flash Point: 192°C
• Appearance: /
• Density: 1.176g/cm³
• Vapor Pressure: 6.59E-07mmHg at 25°C
• Refractive Index: 1.644
• CAS DataBase Reference: 4-Amino-α-phenylbenzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-α-phenylbenzyl alcohol(25782-57-4)
• EPA Substance Registry System: 4-Amino-α-phenylbenzyl alcohol(25782-57-4)

Safety Data

• Hazardous Substances Data: 25782-57-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H13NO/c14-12-8-6-11(7-9-12)13(15)10-4-2-1-3-5-10/h1-9,13,15H,14H2

Upstream product

• 33091-15-5 4-nitrophenyl(phenyl)methanol 
• 1137-41-3 (4-aminophenyl)(phenyl)methanone 
• 40292-19-1 (4-aminophenyl)(4-bromophenyl)methanone 
• 1144-74-7 4-nitrobenzophenone 

Downstream Products

• 309957-83-3 4-(N,N-dimethylamino)-4'-aminotriphenylmethane 
• 1137-41-3 (4-aminophenyl)(phenyl)methanone 
• 101402-02-2 (S)-(4-aminophenyl)(phenyl)methanol 
• 1063170-40-0 (4-isothiocyanatophenyl)(phenyl)methanol 
• 106807-15-2 4-[α-(2-diethylamino-ethoxy)-benzyl]-aniline 
• 100-52-7 benzaldehyde 

Relevant articles and documents

Enhanced catalytic activity of natural hematite-supported ppm levels of Pd in nitroarenes reduction

In this work, Pd NPs supported on amine-modified natural hematite have been prepared and characterized. Using this simple catalyst, nitroaromatic compounds as a major cause of industrial pollution were reduced to corresponding amines with ppm levels of Pd in the presence of designer surfactant TPGS-750-M and NaBH4 at room temperature in aqueous media. Synergistic effect between hematite and Pd is responsible for the observed enhanced catalytic activity. This catalyst was recycled for at least four times with a small decrease in the activity.

Visible-Light-Triggered C-C and C-N Bond Formation by C-S Bond Cleavage of Benzylic Thioethers

The cleavage of sulfidic C-S bonds under visible-light irradiation was harnessed to generate carbocations under neutral conditions and synthesize valuable di- and triarylalkanes as well as benzyl amines. To this end, photoredox catalysis and direct photoinduced C-S bond cleavage are used as complementary approaches and participate in the versatility of the general strategy. Extensive mechanistic studies have demonstrated the diversity of the reaction mechanism at work in these different reactions.

Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors

Human sirtuin 2 (SIRT2) plays pivotal roles in multiple biological processes such as cell cycle regulation, autophagy, immune and inflammatory responses. Dysregulation of SIRT2 was considered as a main aspect contributing to several human diseases, including cancer. Development of new potent and selective SIRT2 inhibitors is currently desirable, which may provide a new strategy for treatment of related diseases. Herein, a structure-based optimization approach led to new 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as SIRT2 inhibitors. SAR analyses with new synthesized derivatives revealed a number of new potent SIRT2 inhibitors, among which 28e is the most potent inhibitor with an IC50 value of 42?nM. The selectivity analyses found that 28e has a very good selectivity to SIRT2 over SIRT1 and SIRT3. In cellular assays, 28e showed a potent ability to inhibit human breast cancer cell line MCF-7 and increase the acetylation of α-tubulin in a dose-dependent manner. This study will aid further efforts to develop highly potent and selective SIRT2 inhibitors for the treatment of cancer and other related diseases.