257933-90-7

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 
• 365281-96-5 (2-oxotetrahydro-thiophen-3-ylamino)-acetic acid tert-butyl ester 

Downstream Products

• 365282-22-0 4-benzylsulfanyl-2-[[(dicyclohexylmethyl-carbamoyl)-methyl]-(4-methoxy-benzenesulfonyl)-amino]-N-trityloxy-butyramide 
• 365282-21-9 4-benzylsulfanyl-2-[{[(di-pyridin-2-yl-methyl)-carbamoyl]-methyl}-(4-methoxy-benzenesulfonyl)-amino]-N-trityloxy-butyramide 
• 365282-19-5 4-benzylsulfanyl-2-[[(cyclohexylmethyl-carbamoyl)-methyl]-(4-methoxy-benzenesulfonyl)-amino]-N-trityloxy-butyramide 
• 365282-20-8 2-[[(benzhydryl-carbamoyl)-methyl]-(4-methoxy-benzenesulfonyl)-amino]-4-benzylsulfanyl-N-trityloxy-butyramide 
• 478944-72-8 4-benzylsulfanyl-2-[cyclohexylcarbamoylmethyl-(4-methoxy-benzenesulfonyl)-amino]-N-trityloxy-butyramide 
• 365282-23-1 4-benzylsulfanyl-2-{(4-methoxy-benzenesulfonyl)-[(4-methoxy-benzylcarbamoyl)-methyl]-amino}-N-trityloxy-butyramide 
• 365282-18-4 4-benzylsulfanyl-2-((4-methoxy-benzenesulfonyl)-{[(pyridin-3-ylmethyl)-carbamoyl]-methyl}-amino)-N-trityloxy-butyramide 
• 365282-26-4 4-benzylsulfanyl-2-[(4-methoxy-benzenesulfonyl)-(2-morpholin-4-yl-2-oxo-ethyl)-amino]-N-trityloxy-butyramide 
• 365282-17-3 2-[(benzylcarbamoyl-methyl)-(4-methoxy-benzenesulfonyl)-amino]-4-benzylsulfanyl-N-trityloxy-butyramide 
• 365282-12-8 4-benzylsulfanyl-2-[[(dicyclohexylmethyl-carbamoyl)-methyl]-(4-methoxy-benzenesulfonyl)-amino]-butyric acid 
• 365282-02-6 4-benzylsulfanyl-2-[[(dicyclohexylmethyl-carbamoyl)-methyl]-(4-methoxy-benzenesulfonyl)-amino]-butyric acid methyl ester 
• 365282-15-1 4-benzylsulfanyl-2-{(4-methoxy-benzenesulfonyl)-[(2,4,6-trimethoxy-benzylcarbamoyl)-methyl]-amino}-butyric acid 
• 365282-05-9 4-benzylsulfanyl-2-{(4-methoxy-benzenesulfonyl)-[(2,4,6-trimethoxy-benzylcarbamoyl)-methyl]-amino}-butyric acid methyl ester 
• 365282-04-8 4-benzylsulfanyl-2-[[(3,5-dimethoxy-benzylcarbamoyl)-methyl]-(4-methoxy-benzenesulfonyl)-amino]-butyric acid methyl ester 

Relevant academic research and scientific papers

N-aryl sulfonyl homocysteine hydroxamate inhibitors of matrix metalloproteinases: Further probing of the S1, S1′, and S2′ pockets

A series of N-arylsulfonyl S-alkyl homocysteine hydroxamic acids were synthesized with variations in three subsites corresponding to P1, P1′, and P2′. Enzyme assays with a variety of MMPs revealed activity at the low nanomolar level.

Picking the S1, S1' and S2' pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors.

A series of acyclic hydroxamic acids harboring strategically placed alpha-arylsulfonamido and thioether groups was synthesized and found to be potent inhibitors of various MMPs. An unprecedented cleavage of t-butyl hydroxamates to hydroxamic acids was found.