257956-91-5

Basic information

• Product Name: N-Cbz-N,O-dimethyltyrosine methyl ester
• CAS NO: 257956-91-5
• Molecular Weight: 357.406
• Mol File: 257956-91-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-Cbz-N,O-dimethyltyrosine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-Cbz-N,O-dimethyltyrosine methyl ester(257956-91-5)
• EPA Substance Registry System: N-Cbz-N,O-dimethyltyrosine methyl ester(257956-91-5)

Safety Data

• Hazardous Substances Data: 257956-91-5(Hazardous Substances Data)

Upstream product

• 5618-98-4 N-α-benzyloxycarbonyl-DL-tyrosine 

Relevant articles and documents

Tamandarins A and B: New cytotoxic depsipeptides from a Brazilian ascidian of the family didemnidae

The structures of two new, naturally occurring cytotoxic depsipeptides, tamandarins A and B (1 and 2) are presented. The tamandarins were isolated from an unidentified Brazilian marine ascidian of the family Didemnidae. The structures of the new cytotoxins were assigned by interpretation of FABMS data and by extensive 2D NMR analyses. The absolute configurations of the tamandarins were assigned by acid and alkaline hydrolysis to yield their corresponding amino acids, which were then analyzed as their Marfey derivatives. The cytotoxicity of tamandarin A (1) was evaluated against various human cancer cell lines and shown to be slightly more potent than didemnin B. A qualitative discussion of the conformation of tamandarin A (1) in solution, obtained from NMR J-value data, variable temperature experiments, and NOESY/ROESY data, is included.