25803-71-8

Usage

Chemical structure

2-[(2-oxo-2-phenylethyl)thio]benzoic acid features a benzene ring with a carboxyl group (-COOH) attached to the 2-position, and a thiol group (-SH) attached to a 2-phenylethyl moiety, which is connected to a ketone group (-C=O).

Noncompetitive inhibitor of histamine (H1) receptors

The compound binds to and blocks the action of histamine at the H1 receptor, which is involved in allergic responses.

Anti-allergy effects

The compound is thought to stabilize mast cells, preventing the release of histamine and other inflammatory mediators that contribute to allergic symptoms.

Anti-inflammatory properties

The compound may inhibit the production of leukotrienes and other pro-inflammatory molecules, which can help reduce inflammation.

Indications

The compound is used for the symptomatic management of allergic conditions, such as allergic rhinitis, conjunctivitis, and atopic dermatitis.

Side effects

The compound is associated with several side effects, including sedation, dry mouth, and dizziness.

Contraindications

The compound should be used with caution in certain patient populations, such as those with narrow-angle glaucoma or urinary retention.

Upstream product

• 147-93-3 Thiosalicylic acid 
• 70-11-1 α-bromoacetophenone 
• 532-27-4 1-chloroacetophenone 

Downstream Products

• 119-80-2 2,2'-dithiobenzoic acid 
• 15776-28-0 2-Benzoyl-3-hydroxybenzothiophene 
• 86296-62-0 2-benzoylbenzothiophen-3(2H)-one 1,1-dioxide 
• 55405-42-0 2-benzoylbenzothiophen-3(2H)-one 

Relevant academic research and scientific papers

Facile synthesis of 2-substituted benzo[b]thiophen-3-ols in water

A facile synthesis of 2-substituted benzo[b]thiophen-3-ols in a simple reaction system is reported with water as the only media. Density functional theory (DFT) investigations suggest two pathways comparable in energetics: A neutral pathway with concerted

BENZOFURANS AND BENZOTHIOPHENES

The invention relates to compounds of the general formula (I), in which R1, R2, R3, R4, R5, R6 and X are as defined in Claim 1. These compounds can be used in the treatment of pathologies associated with insulin resistance syndrome.

Sulfuranes with Oximate Axial Ligands

New sulfuranes having one or two axial oximate (R2C=NO) ligands were synthesized.An improved sulfurane-forming step, involving a rapidly stirred suspension of NaHCO3, is described.The failure of sulfide oximes in which sulfur bears one or two tertiary carbons to form sulfuranes is explained by a C-S bond cleavage leading to tertiary carbocations.This represents a hitherto unanticipated limitation to the standard method of sulfurane synthesis.The X-ray crystal structure of one of the new sulfuranes, namely 2,2'-spirobi(4-phenyl-3H-1,2,5-oxathiazoline), is reported (R = 0.0368).An unusual feature was the quite compressed equatorial (C-S-C) angle, 102.6(1) deg.The S-O bond length, 1.846(2) Angstroem, was similar to S-O bond lenghths of sulfuranes having two axial carboxylate ligands.Since the oximate ligand has not been used previously in a 10-S-4 species, an assessment of its apicophilicity relative to other more common axial ligands was made by considering X-ray structural data, IR data, and ab initio calculations.These suggest that the R2C=NO ligand is as apicophilic as the hexafluorocumyloxy (ArC(CF3)2O) ligand.