15776-28-0

Upstream product

• 532-27-4 1-chloroacetophenone 
• 147-93-3 Thiosalicylic acid 
• 65935-87-7 N,N-diethyl-2-methylsulfanylbenzamide 
• 100-52-7 benzaldehyde 
• 65-85-0 benzoic acid 
• 70-11-1 α-bromoacetophenone 
• 4892-02-8 Methyl thiosalicylate 
• 55819-78-8 2-acetylmercaptobenzoic acid 
• 326-06-7 1-Phenyl-4,4,4-trifluorobutane-1,3-dione 
• 3950-02-5 2-chlorosulfenylbenzoyl chloride 
• 93-91-4 1-phenylbutan-1,3-dione 
• 25803-71-8 2-[(2-oxo-2-phenylethyl)thio]-benzoic acid 
• 3724-10-5 2-(methylthio)benzoic acid 
• 1696-17-9 N,N-diethylbenzamide 

Downstream Products

• 114662-67-8 (3-benzoyloxy-benzo[b]thiophen-2-yl)-phenyl ketone 
• 97457-72-2 (3-acetoxy-benzo[b]thiophen-2-yl)-phenyl-methanone 
• 3844-31-3 trans-thioindigo 
• 77946-49-7 (E)-2-[(amino)-phenylmethylene]-benzo[b]thiophen-3(2H)-one 
• 63114-30-7 (3-hydroxy-1,1-dioxo-1λ⁶-benzo[b]thiophen-2-yl)-phenyl ketone 

Relevant academic research and scientific papers

Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity

A series of benzo[b]thiophen-3-ols were synthesised and investigated as potential human monoamine oxidase (hMAO) inhibitors in vitro as well as ex vivo in rat cortex synaptosomes by means of evaluation of 3,4-dihydroxyphenylacetic acid/dopamine (DOPAC/DA)

Use of Phenacyl Thiosalicylates for the Preparation of 3-Hydroxybenzo[ b ]thiophene Derivatives

In this work, we attempted to synthesize thioflavonols using rearrangement of phenacyl thiosalicylates prepared by two different approaches and subjected to cyclization under acidic conditions. Contrary to our expectations, the isolated products were iden

Facile synthesis of 2-substituted benzo[b]thiophen-3-ols in water

A facile synthesis of 2-substituted benzo[b]thiophen-3-ols in a simple reaction system is reported with water as the only media. Density functional theory (DFT) investigations suggest two pathways comparable in energetics: A neutral pathway with concerted

Iron-ligand coordination in tandem radical cyclizations: Synthesis of benzo[b]thiophenes by a one-pot reaction of iron 1,3-diketone complexes with 2-thiosalicylic acids

Iron-the mediator: 1,3-Diketone ligands coordinated to iron undergo unprecedented tandem reactions with 2-thiosalicylic acids to give 2-substituted 3-hydroxylbenzo[b]thiophenes in up to 98 % yield. A similar reaction with 2-mercaptonicotinic acid gave a thieno[2,3-b]pyridine derivative in 72 % yield (see scheme). A mechanism involving redox transformation and tandem radical cyclization of the coordinated ligands is proposed. Copyright

A simple route to benzo[b]thiophenes: Sulfanylation-acylation of C-H acids with 2-(chlorosulfanyl)benzoyl chloride

A convenient procedure for the preparation of 2,2-disubstituted benzo[b]thiophen3(2H)-ones and 2-substituted 3-hydroxybenzo[b]thiophenes from β-diketones, β-keto- and β-cyanoesters, and β-cyanoketones, diethyl malonate, malonitrile, and anthrone has been

BENZOFURANS AND BENZOTHIOPHENES

The invention relates to compounds of the general formula (I), in which R1, R2, R3, R4, R5, R6 and X are as defined in Claim 1. These compounds can be used in the treatment of pathologies associated with insulin resistance syndrome.

Application of directed metalation in synthesis. Part 8: Interesting example of chemoselectivity in the synthesis of thioaurones and hydroxy ketones and a novel anionic ortho-Fries rearrangement used as a tool in the synthesis of thienopyranones and thiafluorenones

Chemoselective synthesis of thioaurones or 3-hydroxy benzo[b]thiophen-2- aryl ketones, 1-hydroxy naphtho[2,1-b]thiophen-2-aryl ketones and chalcones from N,N-diethyl-ortho-methyl sulfanyl aryl amides were described. (Benzo[b]thiophen-2-yl) alkylates and (naphtho[2,1-b]thiophen-2-yl) alkylates undergo a novel anionic ortho-Fries rearrangement leading to (3-hydroxy benzo[b]thiophen-2-yl) and (1-hydroxy naphtho[2,1-b]thiophen-2-yl) alkyl ketones. The hydroxy ketones were used as intermediates in the synthesis of wide range of benzothienopyranones and thiafluorenones.

Application of directed metalation in synthesis. Part 7: Synthesis of suitably functionalised benzo[b]thiophenes as key intermediates in the synthesis of benzothienopyranones

One-pot syntheses of (3-hydroxybenzo[b]thiophen-2-yl) aryl methanones from ortho-methylsulfanylaryl N,N-diethyl amides and of 1-(3-hydroxybenzo[b]thiophen- 2-yl)ethanone and 1-(3-hydroxybenzo[b]thiophen-2-yl)propan-1-one via an anionic ortho-Fries rearrangement are described. The hydroxy ketones were used as key intermediates in the synthesis of benzothienopyranones.

Activities of 2-carboxanilido 3-hydroxybenzo[b]thiophens against molluscs Biomphalaria

The title compounds are shown to be nearly as active against molluscs as Niclosamide when they are either dihalogenated or monohalogenated and mononitrated on the benzene ring.