25818-83-1

Upstream product

• 100-02-7 4-nitro-phenol 
• 10113-38-9 N-(2-bromophenyl)formamide 
• 13939-06-5 molybdenum hexacarbonyl 
• 104-94-9 4-methoxy-aniline 
• 3342-77-6 N-formylanthranilic acid 
• 610-14-0 2-nitrobenzyl chloride 
• 149-73-5 trimethyl orthoformate 
• 87967-91-7 2-ethoxycarbonyl-3-(4-hydroxyphenyl)-4(3H)quinazolone 
• 22378-45-6 3-(4-Methoxy-phenyl)-3H-quinazolin-4-one 

Downstream Products

• 127780-50-1 3-<4-(2,3-epoxypropoxy)phenyl>-4(3H)quinazolone 
• 127817-72-5 3-(4-{3-[4-(4-Chloro-phenyl)-piperazin-1-yl]-2-hydroxy-propoxy}-phenyl)-3H-quinazolin-4-one 
• 127780-53-4 3-{4-[2-Hydroxy-3-(4-m-tolyl-piperazin-1-yl)-propoxy]-phenyl}-3H-quinazolin-4-one 
• 127780-56-7 3-{4-[2-Hydroxy-3-(4-phenyl-piperazin-1-yl)-propoxy]-phenyl}-3H-quinazolin-4-one 

Relevant academic research and scientific papers

A convenient palladium-catalyzed carbonylative synthesis of 4(3H)-quinazolinones from 2-bromoformanilides and organo nitros with Mo(CO) 6 as a multiple promoter

A novel and convenient procedure for the synthesis of quinazolinones has been developed. Using 2-bromoformanilides and organo nitros as substrates and Mo(CO)6 as a multiple promoter, the desired products were isolated in moderate to excellent yields in the presence of a palladium catalyst. Here, Mo(CO)6 was not only a CO source, but also a nitro compound reducing reagent and a cyclization promoter. This journal is the Partner Organisations 2014.

Efficient solid phase synthesis of diverse quinazolinones

Various quinazolinones were synthesized by cyclocondensation of anthranilamides with a variety of orthoformates on solid supports. Alkyl, aryl and alkoxy groups can substitute at 2 position of quinazolines with this method. The reactions proceeded smoothly under mild acidic conditions and the products exhibited excellent purity. Unlike previously reported solid phase quinazolinone syntheses, this synthetic strategy does not require an oxidation step. The approach is applicable to the synthesis of a wide range of quinazolinones, including molecules that are susceptible to oxidation.

Synthesis, anti-hypertensive and β-adrenoreceptor antagonist activities of 3--phenyl>-4(3H) quinazolones

The synthesis of seven 2-substituted 3--phenyl>-4(3H)quinazolones is described.Pharmacological tests showed that some of the synthesized compounds (3a-c and 3e) possessed pronounced and sustained hypotensive effects,