25871-56-1Relevant articles and documents
AN EXPEDITIOUS ROUTE TO MONOPROTECTED α-KETO ALDEHYDES WITH CONTROL OF REGICHEMISTRY
Babler, James H.
, p. 355 - 358 (2007/10/02)
Treatment of representative orthoesters (2) with pyruvonitrile (3) afforded the corresponding α,α-diethoxynitriles (4) in 65-85percent yields.Subsequent reduction of the latter using lithium aluminium hydride, followed by careful hydrolysis of the aldimine intermediates, led to the procurement of α,α-doalkoxy aldehydes (5) in 80-90percent yield.