25877-49-0

Usage

Uses

Used in Organic Synthesis:
4-(5-METHYL-1,3,4-OXADIAZOL-2-YL)ANILINE is used as a building block in the synthesis of various organic compounds. Its unique structure allows it to be a versatile component in the creation of complex organic molecules, which can be tailored for specific applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-(5-METHYL-1,3,4-OXADIAZOL-2-YL)ANILINE is used as a starting material for the development of new drugs. Its structural properties, including the presence of the aniline and 1,3,4-oxadiazole rings, make it a promising candidate for the design of novel therapeutic agents. 4-(5-METHYL-1,3,4-OXADIAZOL-2-YL)ANILINE's stability and reactivity can be leveraged to create pharmaceuticals with improved efficacy and selectivity.
Used in Medicinal Chemistry:
4-(5-METHYL-1,3,4-OXADIAZOL-2-YL)ANILINE is employed in medicinal chemistry as a key intermediate for the synthesis of bioactive molecules. Its chemical properties enable the formation of diverse chemical entities that can interact with biological targets, potentially leading to the discovery of new drugs with therapeutic benefits.
Used in Drug Design:
In drug design, 4-(5-METHYL-1,3,4-OXADIAZOL-2-YL)ANILINE is utilized as a structural motif to enhance the pharmacological properties of drug candidates. Its incorporation into drug molecules can improve their stability, solubility, and binding affinity to target proteins, thereby increasing their therapeutic potential.
Overall, 4-(5-METHYL-1,3,4-OXADIAZOL-2-YL)ANILINE is a valuable chemical entity with a wide range of applications in organic synthesis, pharmaceutical research, medicinal chemistry, and drug design. Its unique structural features and potential for further modification make it an attractive candidate for the development of innovative pharmaceuticals and organic compounds.

Upstream product

• 22816-00-8 N'-acetyl-4'-nitrobenzohydrazide 
• 636-97-5 N-amino-(4-nitrophenyl)carboxamide 
• 122-04-3 4-nitro-benzoyl chloride 
• 22815-99-2 2-methyl-5-(4-nitrophenyl)-1,3,4-oxadiazole 

Downstream Products

• 1578247-13-8 2-chloro-4-(5-methyl-1,3,4-oxadiazol-2-yl)aniline 
• 1187889-70-8 N-[4-(5-methyl-[1,3,4]oxadiazol-2-yl)-phenyl]-3-oxo-3-[4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-propionamide 

Relevant academic research and scientific papers

Isoxazoline derivative and application thereof in agriculture

The invention provides an isoxazoline derivative and an application thereof in agriculture. The invention provides a novel isoxazoline derivative and a preparation method thereof; a composition containing the compounds and an application of the compositio

Synthesis and methemoglobinemia-inducing properties of benzocaine isosteres designed as humane rodenticides

A number of isosteres (oxadiazoles, thiadiazoles, tetrazoles and diazines) of benzocaine were prepared and evaluated for their capacity to induce methemoglobinemia - with a view to their possible application as humane pest control agents. It was found that an optimal lipophilicity for the formation of methemoglobin (metHb) in vitro existed within each series, with 1,2,4-oxadiazole 3 (metHb% = 61.0 ± 3.6) and 1,3,4-oxadiazole 10 (metHb% = 52.4 ± 0.9) demonstrating the greatest activity. Of the 5 candidates (compounds 3, 10, 11, 13 and 23) evaluated in vivo, failure to induce a lethal end-point at doses of 120 mg/kg was observed in all cases. Inadequate metabolic stability, particularly towards hepatic enzymes such as the CYPs, was postulated as one reason for their failure.

NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE

The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

HYDRAZONE DERIVATIVE

A compound represented by the following formula (I): wherein R1 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R2 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R3 represents hydrogen, etc.; Ar represents a divalent group derived from aromatic hydrocarbon, etc.; X represents a single bond, linear or branched alkylene having from 1 to 3 carbon atoms which may have a substituent, etc.; and G represents halogen, a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc., a salt thereof or a solvate thereof; and an agent for inhibiting aggregation and/or deposition of an amyloid protein or an amyloid-like protein, which comprises the compound, a salt thereof or a solvate thereof