25878-56-2Relevant articles and documents
Synthesis of a New Branched Chain Hexopyranosyl Nucleoside: 1--thymine
Augustyns, K.,Rozenski, J.,Aerschot, A. Van,Busson, R.,Claes, P.,Herdewijn, P.
, p. 1189 - 1198 (2007/10/02)
A straightforward synthesis of the branched chain nucleoside 7 is described.This synthesis involves two stereoselective steps: introduction of the hydroxymethyl group on the sugar is achieved by radical cyclization of the (bromomethyl)dimethylsilyl ether of the allylic alcohol 8; the condensation reaction with thymine as base moiety resulted exclusively in the formation of the α-anomer.
