258846-65-0

Upstream product

• 258846-58-1 {(2R,3R)-3-[(1S,2R)-1-Benzyloxymethyl-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-oxiranyl}-methanol 
• 258846-63-8 (E)-(4R,5R)-4-Benzyloxymethyl-5-(tert-butyl-dimethyl-silanyloxy)-hex-2-en-1-ol 
• 258846-61-6 (2R,3R)-2-[(benzyloxy)methyl]-3-(tert-butyldimethylsiloxy)butan-1-ol 
• 107441-56-5 methyl (2R,3R)-2-[(benzyloxy)methyl]-3-(tert-butyldimethylsiloxy)butyrate 
• 107441-54-3 (2R,3R)-methyl 2-[(benzyloxy)methyl]-3-hydroxybutyrate 
• 3587-60-8 Benzyloxymethyl chloride 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 258846-74-1 (2S,3S,4S,5R)-4-Benzyloxymethyl-5-(tert-butyl-dimethyl-silanyloxy)-2-methyl-hexane-1,3-diol 

Downstream Products

• 258846-76-3 Methanesulfonic acid (1S,2R,3R)-2-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-1-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-butyl ester 
• 258846-78-5 {(2R,3S,4R)-3-Azido-5-(tert-butyl-dimethyl-silanyloxy)-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-methyl-pentyloxymethyl}-benzene 

Relevant academic research and scientific papers

A new diastereoselective synthesis of a 1β-methylcarbapenem intermediate

A 1β-methylcarbapenem key intermediate is synthesized from methyl (R)- 3-hydroxybutyrate via the diastereoselective alkylation and regioselective cuprate ring opening of a chiral epoxide which is readily prepared from Sharpless asymmetric epoxidation of the corresponding allylic alcohol.