25907-29-3Relevant academic research and scientific papers
NOVEL PYRROLE DERIVATIVES FOR THE TREATMENT OF CANCER
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Page/Page column 38, (2014/10/15)
The invention provides a method for the treatment of cancer, which method comprises the general formula (I) wherein R1, R2, R3, R4 and W are as described herein.
Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacy
Sherer, Brian A.,Hull, Kenneth,Green, Oluyinka,Basarab, Gregory,Hauck, Sheila,Hill, Pamela,Loch III, James T.,Mullen, George,Bist, Shanta,Bryant, Joanna,Boriack-Sjodin, Ann,Read, Jon,Degrace, Nancy,Uria-Nickelsen, Maria,Illingworth, Ruth N.,Eakin, Ann E.
scheme or table, p. 7416 - 7420 (2012/02/04)
The pyrrolamides are a new class of antibacterial agents targeting DNA gyrase, an essential enzyme across bacterial species and inhibition results in the disruption of DNA synthesis and subsequently, cell death. The optimization of biochemical activity an
2-(PIPERIDIN-1-YL)-4-AZOLYL-THIAZOLE-5-CARBOXYLIC ACID DERIVATIVES AGAINST BACTERIAL INFECTIONS
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Page/Page column 71, (2010/07/02)
Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described
