848498-76-0Relevant articles and documents
7-site substituted pyrrolotriazine compounds or pharmaceutically available salt thereof, and preparation method and use thereof
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Paragraph 0061-0062, (2019/01/10)
The present invention relates to 7-site substituted pyrrole [2,1-f][1,2,4] triazine compounds or pharmaceutically acceptable salts thereof, and a preparation method therefor and uses thereof. This kind of compound shows good PI3K inhibition activity, can effectively inhibit the activity of the PI3K kinase; and due to the introduction of 7-site groups, bioavailability and other pharmacokinetic properties have been greatly improved. In addition, the compounds in the present invention show an unpredictable high selectivity and strong inhibitory activity on PI3kdelta, accordingly, the compounds can be used to treat diseases associated with PI3K pathways, especially for resisting against cancers or treatment of tumors, leukemia and autoimmune diseases. After further optimization and screening,the compounds are expected to develop into new antitumor drugs.
2-(PIPERIDIN-1-YL)-4-AZOLYL-THIAZOLE-5-CARBOXYLIC ACID DERIVATIVES AGAINST BACTERIAL INFECTIONS
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Page/Page column 72-73, (2010/07/02)
Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described
