259100-41-9

Upstream product

• 127199-95-5 2-amino-5-mercapto-thiazolo[4,5-d]pyrimidin-7-ol 
• 259103-40-7 {[4-amino-2-(benzylsulfanyl)-6-hydroxypyrimidin-5-yl]sulfanyl}formonitrile 
• 259100-47-5 2-amino-5-(benzylsulfanyl)[1,3]thiazolo[4,5-d]pyrimidin-7-ol 
• 676345-24-7 C₁₂H₈F₂N₄OS₂ 
• 127199-95-5 2-Amino-5-mercapto-thiazolo[4,5-d]pyrimidin-7(4H)-one 
• 113211-94-2 2,3-difluorobenzyl bromide 
• 127199-95-5 5-amino-1,2,3,7-tetrahydro-7-oxo-2-thioxothiazolo<4.5-d>-pyrimidine 
• 676345-24-7 4-amino-2-[[(2,3-difluorophenyl)methyl]thio]-1,6-dihydro-6-oxo-5-pyrimidinyl ester thiocyanic acid 
• 503271-69-0 6-amino-2-[[(2,3-difluorophenyl)methyl]thio]-4(3H)-pyrimidinone 

Downstream Products

• 259101-64-9 5-[[(2,3-Difluorophenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7(4H)-one 
• 259103-43-0 7-chloro-5-[(2,3-difluorobenzyl)sulfanyl][1,3]thiazolo[4,5-d]pyrimidin-2-amine 
• 676345-71-4 2-({2-chloro-5-[((2,3-difluorophenyl)methyl)thio]thiazolo[4,5-d]pyrimidin-7-yl}amino)-(2S,3S)-butane-1,3-diol 
• 676345-69-0 5-[((2,3-difluorophenyl)methyl)thio]-7-{[(1S,2S)-2-hydroxy-1-(hydroxymethyl)propyl]amino}thiazolo[4,5-d]pyrimidin-2(3H)-one 
• 676345-23-6 5-[[(2,3-difluorophenyl)methyl]thio]-7-[[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]amino]-thiazolo[4,5-d]pyrimidin-2(3H)-one, monosodium salt 
• 676345-25-8 2-[[2-chloro-5-[[(2,3-difluorophenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-2-methyl-1,3-propanediol 

Relevant academic research and scientific papers

Evaluation of a series of bicyclic CXCR2 antagonists

The CXCR2 SAR of a series of bicyclic antagonists such as the 2-aminothiazolo[4,5-d]pyrimidine 3b was investigated by systematic variation of the fused pyrimidine-based heterocyclic cores. Replacement of the aminothiazole ring with a 2-thiazolone alternat

Hit-to-Lead studies: The discovery of potent, orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists

A Hit-to-Lead optimisation programme was carried out on a high throughput screening hit, the thiazolopyrimidine 1, resulting in the discovery of the potent, orally bioavailable CXCR2 antagonist 29.

NOVEL COMPOUND

A compound of formula (I) and pharmaceutically acceptable salts or solvates thereof for use in therapy.

NOVEL COMPOUND

A compound of formula (I) and pharmaceutically acceptable salts or solvates thereof for use in therapy.

Thiazolo (4,5-D) pyrimidine compounds

The invention provides certain thiazolopyrimidine compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof; processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therap

NOVEL THIAZOLOPYRIMIDINE COMPOUNDS

The invention provides certain thiazolopyrimidine compounds, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.