259227-40-2

Upstream product

• 54125-02-9 danishefsky's diene 
• 100-52-7 benzaldehyde 

Downstream Products

• 40989-96-6 2-phenyl-2,3-dihydropyran-4-one 
• 88198-68-9 (R)-2-phenyl-2,3-dihydro-4H-pyran-4-one 
• 40989-96-6 (2S)-2-phenyl-2,3-dihydro-4H-pyran-4-one 

Relevant academic research and scientific papers

Nafion-H-catalyzed Mukaiyama aldol condensations and hetero Diels-Alder reactions using aldehydes and imines. Part 15: General synthetic methods

Nafion-H catalyzes the Mukaiyama aldol condensation between aromatic aldehydes and the Danishefsky diene whereas the corresponding imines directly undergo hetero Diels-Alder cyclization to form 2,3-dihydro-γ-pyridones. Some chiral acetal derived aldehydes

Asymmetric cycloaddition reactions

The present invention relates to a process for stereoselective cycloaddition reactions which generally comprises a cycloaddition reaction between a pair of substrates, each either chiral or prochiral, that contain reactive π-systems, in the presence of a non-racemic chiral catalyst, to produce a stereoisomerically enriched product. The present invention also relates to novel asymmetric catalyst complexes comprising a metal and an asymmetric tridentate ligand.