25939-12-2

Basic information

• Product Name: 4-Bromobenzoyl chloride phenylhydrazone
• Synonyms: 4-Bromobenzoyl chloride phenylhydrazone;1-[(4-Bromophenyl)chloromethylene]-2-phenylhydrazine
• CAS NO: 25939-12-2
• Molecular Formula: C₁₃H₁₀BrClN₂
• Molecular Weight: 309.5889
• Mol File: 25939-12-2.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 384.5°Cat760mmHg
• Flash Point: 186.3°C
• Appearance: /
• Density: 1.43g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 4-Bromobenzoyl chloride phenylhydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromobenzoyl chloride phenylhydrazone(25939-12-2)
• EPA Substance Registry System: 4-Bromobenzoyl chloride phenylhydrazone(25939-12-2)

Safety Data

• Hazardous Substances Data: 25939-12-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H10BrClN2/c14-11-8-6-10(7-9-11)13(15)17-16-12-4-2-1-3-5-12/h1-9,16H/b17-13-

Upstream product

• 63877-70-3 p-bromobenzoic acid phenylhydrazide 
• 16917-42-3 4-bromobenzaldehyde phenylhydrazone 
• 1122-91-4 4-bromo-benzaldehyde 
• 100-63-0 phenylhydrazine 
• 586-75-4 4-chlorobenzoyl chloride 
• 586-76-5 4-Bromobenzoic acid 
• 25938-97-0 4-bromo-N'-phenylbenzohydrazide 

Downstream Products

• 32527-72-3 3-(4-bromo-phenyl)-4ξ,6ξ-dimethoxy-1-phenyl-(3ar,6ac)-3a,4,6,6a-tetrahydro-1H-furo[3,4-c]pyrazole 
• 132703-76-5 N-[1-Benzoimidazol-1-yl-1-(4-bromo-phenyl)-meth-(E)-ylidene]-N'-phenyl-hydrazine 
• 132703-82-3 N-[1-(4-Bromo-phenyl)-1-[1,2,4]triazol-4-yl-meth-(E)-ylidene]-N'-phenyl-hydrazine 
• 1112193-92-6 2-(2-(3-(4-bromophenyl)-1-phenyl-1H-pyrazol-5-yl)propan-2-yl)-N-methylaniline 
• 1308660-72-1 C₂₁H₁₉BrN₂O₂ 
• 1308660-68-5 C₂₁H₁₉BrN₂O₂ 
• 1308660-65-2 C₂₂H₂₃BrN₂O₃ 
• 1354908-57-8 (3aS,6aS)-3-(4-bromophenyl)-5,6a-dihydro-1-phenyl-5-[(1R)-1-phenylethyl]pyrrolo[3,4-c]pyrazole-4,6(1H,3aH)dione 
• 1402665-57-9 3-(4-bromophenyl)-1,5-diphenyl-4-(trifluoromethylsulfonyl)-1H-pyrazole 
• 33064-18-5 3-(4-bromophenyl)-1-phenyl-1H-pyrazole 
• 929606-89-3 3-(4-bromophenyl)-5-(trifluoromethyl)-1-phenyl-1H-pyrazole 

Relevant articles and documents

Blatter-Radical-Grafted Mesoporous Silica as Prospective Nanoplatform for Spin Manipulation at Ambient Conditions

Quantum computing and quantum information processing (QC/QIP) crucially depend on the availability of suitable quantum bits (qubits) and methods of their manipulation. Most qubit candidates known to date are not applicable at ambient conditions. Herein, we propose radical-grafted mesoporous silica as a versatile and prospective nanoplatform for spin-based QC/QIP. Extremely stable Blatter-type organic radicals are used, whose electron spin decoherence time is profoundly long even at room temperature (up to Tm≈2.3 μs), thus allowing efficient spin manipulation by microwave pulses. The mesoporous structure of such composites is nuclear-spin free and provides additional opportunities of embedding guest molecules into the channels. Robustness and tunability of these materials promotes them as highly promising nanoplatforms for future QC/QIP developments.

Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2-Substituted-Alkynyl-1-Sulfonyl Fluoride (SASF) Hubs

Diversity Oriented Clicking (DOC) is a unified click-approach for the modular synthesis of lead-like structures through application of the wide family of click transformations. DOC evolved from the concept of achieving “diversity with ease”, by combining classic C?C π-bond click chemistry with recent developments in connective SuFEx-technologies. We showcase 2-Substituted-Alkynyl-1-Sulfonyl Fluorides (SASFs) as a new class of connective hub in concert with a diverse selection of click-cycloaddition processes. Through the selective DOC of SASFs with a range of dipoles and cyclic dienes, we report a diverse click-library of 173 unique functional molecules in minimal synthetic steps. The SuFExable library comprises 10 discrete heterocyclic core structures derived from 1,3- and 1,5-dipoles; while reaction with cyclic dienes yields several three-dimensional bicyclic Diels–Alder adducts. Growing the library to 278 discrete compounds through late-stage modification was made possible through SuFEx click derivatization of the pendant sulfonyl fluoride group in 96 well-plates—demonstrating the versatility of the DOC approach for the rapid synthesis of diverse functional structures. Screening for function against MRSA (USA300) revealed several lead hits with improved activity over methicillin.

A [4 + 3] Annulation Reaction of aza- o-Quinone Methides with Arylcarbohydrazonoyl Chlorides for Synthesis of 2,3-Dihydro-1 H-benzo[ e][1,2,4]triazepines

An unprecedented [4 + 3] annulation reaction of aza-ortho-quinone methides with arylcarbohydrazonoyl chlorides has been achieved under mild conditions. The annulation underwent a sequential conjugate addition/intramolecular annulation/rearrangement, providing a useful method for the synthesis of biologically interesting 2,3-dihydro-1H-benzo[e][1,2,4]triazepine.