25960-27-4

Upstream product

• 25960-26-3 3-(p-methoxyphenyl)-5-phenylcyclohex-2-en-1-one 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 22966-19-4 trans-4'-methoxychalcone 
• 100-52-7 benzaldehyde 
• 84725-18-8 4-carbomethoxy-1-(p-methoxyphenyl)-5-phenyl-cyclohex-1-en-3-one 

Downstream Products

• 84750-33-4 3--5-phenylcyclohex-2-en-1-one 

Relevant academic research and scientific papers

Studies in Antifertility Agents: Part XXXVII--Synthesis of 3-Aryl-5-phenylcyclohex-2-en-1-ones and 4,6-Diphenyl-2,3-disubstituted-benzopyrazoles

Condensation of methyl acetoacetate with 4'-methoxychalkone (1) gives 6-carbomethoxy-3-(p-methoxyphenyl)-5-phenylcyclohex-2-en-1-one (2) which on reaction with hydrazine hydrate and phenylhydrazine yields 3-oxo-4,6-diphenyl-3,3a,4,5-tetrahydrobenzopyrazoles (3 and 4).Treatment of 2 with aq.H2SO4-AcOH results in decarboxylation to yield the corresponding cyclohexenone (6) which on KBH4 reduction gives cyclohexen-1-ol (7).Acetylation of 3 and 7 gives the respective acetates (5 and 7).Demethylation of 6 affords the corresponding 3-(p-hydroxyphenyl) derivative (9) which on treatment with 1-(β-chloroethyl)pyrrolidine furnishes the desired compound, 3--5-phenylcyclohex-2-en-1-one (10).None of the compounds prevents pregnancy in female albino rats at 10 mg/kg dose.