259856-82-1Relevant articles and documents
A new route to (2S,4R)- and (2R,4S)-4-hydroxypipecolic acid
Haddad, Mansour,Larcheveque, Marc
, p. 4231 - 4237 (2007/10/03)
Both enantiomers of cis-4-hydroxypipecolic acid have been prepared by asymmetric synthesis using (S)- or (R)-glycidol as the chiral source, and involving a stereoselective hydrogenation of a six-membered cyclic imine. The latter is obtained by reduction and cyclization of a cyano β-hydroxy ketone.