259856-84-3

Upstream product

• 5425-44-5 2-Phenyl-[1,3]dithiane 
• 78906-15-7 tert-butyldimethylsilyl (S)-glycidyl ether 

Downstream Products

• 259856-83-2 (2S,4R)-(-)-2-Phenylpiperidine-4-ol 
• 259856-82-1 (3R)-3-hydroxy-5-oxo-5-phenylpentanenitrile 
• 259856-85-4 (2S)-4-(1,3-dithian-2-yl)-1,2-epoxy-4-phenylbutane 
• 259856-86-5 (3R)-5-(1,3-dithian-2-yl)-3-hydroxy-5-phenylpentanenitrile 
• 259856-87-6 (2S,4R)-(-)-4-Acetoxy-2-phenyl-1-trifluoroacetylpiperidine 
• 1026470-49-4 Trifluoro-acetic acid (2S,4R)-2-phenyl-1-(2,2,2-trifluoro-acetyl)-piperidin-4-yl ester 

Relevant academic research and scientific papers

A new route to (2S,4R)- and (2R,4S)-4-hydroxypipecolic acid

Both enantiomers of cis-4-hydroxypipecolic acid have been prepared by asymmetric synthesis using (S)- or (R)-glycidol as the chiral source, and involving a stereoselective hydrogenation of a six-membered cyclic imine. The latter is obtained by reduction and cyclization of a cyano β-hydroxy ketone.