259862-91-4

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 6640-65-9 N-(2-hydroxyethyl)-4-nitrobenzamide 
• 54472-45-6 N-(2-Hydroxyethyl)-4-aminobenzamide 
• 108-95-2 phenol 

Downstream Products

• 259862-92-5 4-(2'-O-dimethoxytrityl ethyl-oxy)-4'-(N-hydroxyethyl)azobenzamide 

Relevant academic research and scientific papers

Synthesis of oligonucleotides containing a new azobenzene fragment with efficient photoisomerizability

The azobenzene derivatives possessing substituents of ROCH2CH2O- and-CH2CH2OR' or -CONHCH2CH2OR' at p,p'-positions, where R and R' are 4,4'-dimethoxytrityl and 2-cyanoethyl-N,N'-diisopropylphophoramidite, have been synthesized for linking two oligonucelotide segments. It has been found that the azobenzene linkers efficiently undergo trans-cis isomerization by exposing to UV light. The conversion efficiency showed slight dependence on structure or conformation of oligonucleotides attached to the azobenzene chromophore. The cis-form of the azobenzene in oligonucleotides was sufficiently stable at low temperature under dark. The present findings would open the way for light switch of nucleic acid structures. Copyright (C) 1999 Elsevier Science Ltd.