259867-07-7Relevant articles and documents
Synthesis of the cyclic heptapeptide Substance P antagonist, dihydro-WIN67689 and determination of the stereochemistry of the modified tyrosine moiety
Li, Yuan-Qiang,Sugase, Kenji,Ishiguro, Masaji
, p. 9097 - 9100 (2007/10/03)
The total synthesis of semi-synthetic cyclic heptapeptide dihydro-WIN67689, a Substance P antagonist 70 times more potent than the naturally occurring cyclic peptide WIN66306, established the stereochemistry of the β-OH group in the isoprenyltyrosine moiety in I-III as R.