259867-13-5

Upstream product

• 259867-09-9 1-[2-(2-{2-{2-[2-(2-benzyloxycarbonylamino-acetylamino)-3-methyl-butyrylamino]-acetylamino}-3-hydroxy-3-[4-methoxy-3-(3-methyl-butyl)-phenyl]-propionylamino}-acetylamino)-3-(1H-indol-3-yl)-propionyl]-pyrrolidine-2-carboxylic acid benzyl ester 
• 151071-00-0 4-bromo-2-(3-methylbut-2-en-1-yl)phenol 
• 56074-98-7 4-Methoxy-3-(γ,γ-dimethylallyl)benzaldehyde 
• 106-41-2 4-bromo-phenol 
• 151928-34-6 cyclic Pro-Gly-Val-Gly-Tyr(β-OH,3-prenyl,4-methyl)-Gly-Trp 
• 259867-07-7 (2S,3R)-2-{2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-3-methyl-butyrylamino]-acetylamino}-3-hydroxy-3-[4-methoxy-3-(3-methyl-butyl)-phenyl]-propionic acid methyl ester 
• 259867-00-0 (R)-((2S,5R)-5-Isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-[4-methoxy-3-(3-methyl-but-2-enyl)-phenyl]-methanol 
• 259867-05-5 (2S,3R)-2-Amino-3-hydroxy-3-[4-methoxy-3-(3-methyl-but-2-enyl)-phenyl]-propionic acid methyl ester 
• 187400-01-7 4-Bromo-1-methoxy-2-(3-methyl-but-2-enyl)-benzene 
• 870-63-3 prenyl bromide 

Relevant academic research and scientific papers

Synthesis of the cyclic heptapeptide Substance P antagonist, dihydro-WIN67689 and determination of the stereochemistry of the modified tyrosine moiety

The total synthesis of semi-synthetic cyclic heptapeptide dihydro-WIN67689, a Substance P antagonist 70 times more potent than the naturally occurring cyclic peptide WIN66306, established the stereochemistry of the β-OH group in the isoprenyltyrosine moiety in I-III as R.

Structure determination, pharmacological evaluation, and structure- activity studies of a new cyclic peptide substance P antagonist containing the new amino acid 3-prenyl-β-hydroxytyrosine, isolated from Aspergillus flavipes

Two novel cyclic heptapeptides, peptides 1a and 1c, were isolated from an Aspergillus flavipes culture, originally isolated from soil, and their structures established by chemical and spectroscopic evidence. Peptide 1a contains a new amino acid, 3-prenyl-