259867-13-5

Basic information

• Product Name: cyclic Pro-Gly-Val-Gly-Tyr(β-OH,4-methyl,3-(2-methylbutyl))-Gly-Trp
• Synonyms: cyclic Pro-Gly-Val-Gly-Tyr(β-OH,4-methyl,3-(2-methylbutyl))-Gly-Trp
• CAS NO: 259867-13-5
• Molecular Weight: 816.955
• Mol File: 259867-13-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: cyclic Pro-Gly-Val-Gly-Tyr(β-OH,4-methyl,3-(2-methylbutyl))-Gly-Trp(CAS DataBase Reference)
• NIST Chemistry Reference: cyclic Pro-Gly-Val-Gly-Tyr(β-OH,4-methyl,3-(2-methylbutyl))-Gly-Trp(259867-13-5)
• EPA Substance Registry System: cyclic Pro-Gly-Val-Gly-Tyr(β-OH,4-methyl,3-(2-methylbutyl))-Gly-Trp(259867-13-5)

Safety Data

• Hazardous Substances Data: 259867-13-5(Hazardous Substances Data)

Upstream product

• 151071-00-0 4-bromo-2-(3-methylbut-2-en-1-yl)phenol 
• 259867-09-9 1-[2-(2-{2-{2-[2-(2-benzyloxycarbonylamino-acetylamino)-3-methyl-butyrylamino]-acetylamino}-3-hydroxy-3-[4-methoxy-3-(3-methyl-butyl)-phenyl]-propionylamino}-acetylamino)-3-(1H-indol-3-yl)-propionyl]-pyrrolidine-2-carboxylic acid benzyl ester 
• 259867-07-7 (2S,3R)-2-{2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-3-methyl-butyrylamino]-acetylamino}-3-hydroxy-3-[4-methoxy-3-(3-methyl-butyl)-phenyl]-propionic acid methyl ester 
• 259867-00-0 (R)-((2S,5R)-5-Isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-[4-methoxy-3-(3-methyl-but-2-enyl)-phenyl]-methanol 
• 259867-05-5 (2S,3R)-2-Amino-3-hydroxy-3-[4-methoxy-3-(3-methyl-but-2-enyl)-phenyl]-propionic acid methyl ester 
• 187400-01-7 4-Bromo-1-methoxy-2-(3-methyl-but-2-enyl)-benzene 
• 870-63-3 prenyl bromide 
• 56074-98-7 4-Methoxy-3-(γ,γ-dimethylallyl)benzaldehyde 
• 106-41-2 4-bromo-phenol 
• 151928-34-6 cyclic Pro-Gly-Val-Gly-Tyr(β-OH,3-prenyl,4-methyl)-Gly-Trp 

Relevant articles and documents

Synthesis of the cyclic heptapeptide Substance P antagonist, dihydro-WIN67689 and determination of the stereochemistry of the modified tyrosine moiety

The total synthesis of semi-synthetic cyclic heptapeptide dihydro-WIN67689, a Substance P antagonist 70 times more potent than the naturally occurring cyclic peptide WIN66306, established the stereochemistry of the β-OH group in the isoprenyltyrosine moiety in I-III as R.