25991-45-1

Basic information

• Product Name: 1-sec-butyl-piperidine
• Synonyms: Piperidine,1-sec-butyl- (8CI); 1-sec-Butylpiperidine; N-sec-Butylpiperidine
• CAS NO: 25991-45-1
• Molecular Formula: C9H19 N
• Molecular Weight: 141.25
• Mol File: 25991-45-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 175-176 °C(Press: 768 Torr)
• Appearance: /
• Density: 0.8378 g/cm3
• PKA: 10.43±0.50(Predicted)
• CAS DataBase Reference: 1-sec-butyl-piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-sec-butyl-piperidine(25991-45-1)
• EPA Substance Registry System: 1-sec-butyl-piperidine(25991-45-1)

Safety Data

• Hazardous Substances Data: 25991-45-1(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 715-11-7 2-tosyloxybutane 
• 78-92-2 iso-butanol 
• 75-16-1 methylmagnesium bromide 
• 87967-99-5 2-Chloro-1-piperidin-1-yl-butan-1-one 
• 14045-28-4 N-propionylpiperidine 
• 917-54-4 methyllithium 
• 75505-86-1 1-s-butyl-2,4,6-triphenylpyridinium 
• 513-48-4 2-butyl iodide 
• 78-76-2 s-butyl bromide 
• 111-24-0 1,5-dibromo-pentane 
• 13250-12-9 (R)-sec-butylamine 

Relevant articles and documents

Amination of aliphatic alcohols catalyzed by CuO-NiO/γ-Al 2O3

The amination of aliphatic alcohols in the gas-solid phase was investigated in a fixed-bed reactor in the presence of CuO-NiO/γ-Al2O 3 as the catalyst. This catalytic system was successfully applied for both the N-methylation of aliphatic amines and N-alkylation of piperidine with primary or secondary alcohols. N-Alkylation of piperidine with low-carbon alcohols resulted in high conversions and selectivities, and the conversion of piperidine and the selectivities toward the desired products declined gradually with the increase of the carbon number of aliphatic alcohols. The influence of varied conditions on the N-cyclohexylation of piperidine was also evaluated, including liquid hourly space velocity (LHSV), temperature and the catalyst; especially the catalyst had the greatest impact. Finally, the test of the catalyst's stability was performed.

A Synthesis of α-Substituted Amines

The reaction of amides with organolithium reagents followed by hydride reducing agents has been studied as a synthetic route to α-substituted amines.The stereochemistry of the amine has been observed to depend upon the nature of the reducing agent.

Kinetics and Mechanisms of Nucleophilic Displacements with Heterocycles as Leaving Groups. Part 5. Solvent Effects

First- and second-order rates for the reactions of 1-methyl-, 1-isopropyl-, 1-s-butyl-, 1-benzyl-, and 1-p-methoxybenzyl-2,4,6-triphenylpyridiniums with piperidine in chlorobenzene in protic and dipolar aprotic solvents are reported.For the 1-isopropyl, 1-s-butyl and 1-p-methoxybenzyl derivatives the bimolecular reaction is accompanied by a unimolecular process in all solvents.Second-order rate constants for the 1-methyl and for the 1-benzyl compounds are correlated with the ET solvent parameter.Principal component analysis of second-order rates provided a three-component model.The first component differentiates aprotic solvents from protic ones, while the second component is linearly related to the basicity parameter B for aprotic solvents.