364385-54-6

Basic information

• Product Name: Carbamic acid, [(1R,2S)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, [(1R,2S)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI);Cis-(1R, 2S)-1N-Boc-cyclohexane-1,2-diamine;tert-butyl (1R,2S)-2-aminocyclohexylcarbamate;N-Boc-1(R),2(S)-diaminocyclohexane;tert-Butyl N-[(1R,2S)-2-aminocyclohexyl]carbamate;(1R,2S)-Cyclohexane-1,2-diamine, 1-BOC protected;tert-Butyl [(1R,2S)-2-aminocyclohex-1-yl]carbamate, (1R,2S)-1,2-diaminocyclohexane, N1-BOC protected;(1R,2S)-N1-(tert-Butoxycarbonyl)-1,2-cyclohexanediaMine
• CAS NO: 364385-54-6
• Molecular Formula: C₁₁H₂₂N₂O₂
• Molecular Weight: 214.30458
• Product Categories: N-BOC
• Mol File: 364385-54-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 181-183 °C
• Boiling Point: 322.1±31.0 °C(Predicted)
• Appearance: /
• Density: 1.02±0.1 g/cm3(Predicted)
• Storage Temp.: 0-10°C
• Solubility: soluble in dichloromethane
• PKA: 12.26±0.40(Predicted)
• CAS DataBase Reference: Carbamic acid, [(1R,2S)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1R,2S)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI)(364385-54-6)
• EPA Substance Registry System: Carbamic acid, [(1R,2S)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI)(364385-54-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 364385-54-6(Hazardous Substances Data)

Usage

Description

Carbamic acid, [(1R,2S)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI) is a chemical compound with the molecular formula C11H21NO2. It is an ester derivative of carbamic acid, characterized by its 1,1-dimethylethyl ester group attached to the cyclohexylamine moiety. Carbamic acid, [(1R,2S)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI) is commonly used as a pharmaceutical intermediate in the synthesis of various drugs and has potential applications in chemical research and development. Its unique structure and properties make it a subject of interest for further study in the fields of pharmacology and medicinal chemistry.

Uses

Used in Pharmaceutical Industry:
Carbamic acid, [(1R,2S)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI) is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique structure allows it to be a key component in the development of new pharmaceuticals with potential therapeutic applications.
Used in Chemical Research and Development:
Carbamic acid, [(1R,2S)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI) is also used in chemical research and development, where its unique properties can be explored and utilized for the creation of new chemical entities and the advancement of scientific knowledge.
Used in Medicinal Chemistry:
Carbamic acid, [(1R,2S)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI) has important biological and medicinal properties, making it a subject of interest for further study in the field of medicinal chemistry. Its potential applications in the development of new drugs and therapeutic agents are being investigated.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1436-59-5 cis-cyclohexane-1,2-diamine 
• 694-83-7 rac-diaminocyclohexane 
• 364385-60-4 tert-butyl [(1R,2S)-2-(phthalimido)cyclohexyl]-carbamate 
• 260065-86-9 (1R,2S)-2-amino-1-cyclohexanol 
• 115586-44-2 Butyric acid (1S,2S)-2-azido-cyclohexyl ester 
• 119479-49-1 (1S,2S)-trans-2-azidocyclohexanol 
• 603128-64-9 (1R,2R)-2-(N-tert-butoxycarbonylamino)-cyclohexan-1-yl methanesulfonate 
• 155975-19-2 (1R,2R)-trans-2-(N-tert-butyloxycarbonyl)amino-1-cyclohexanol 
• 286-20-4 cyclohexane-1,2-epoxide 
• 110716-78-4 (1R,2R)-trans-2-azidocyclohexanol 
• 603128-65-0 (1S,2R)-2-(N-tert-butyloxycarbonylamino)-1-azidocyclohexane 

Downstream Products

• 603128-68-3 N-[(2R)-tert-butyloxycarbonylaminocyclohex-(1S)-yl]-N-(chloroacetyl)glycine ethyl ester 
• 603128-70-7 N-[(2R)-tert-butyloxycarbonylaminocyclohex-(1S)-yl]-N-(thymin-1-ylacetyl)glycine ethyl ester 
• 365996-30-1 tert-butyl ((1S,2R)-2-aminocyclohexyl)carbamate 
• 1370261-98-5 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1R, 2S)-2-aminocyclohexylamino)pyrimidine-5-carboxamide acetic acid salt 
• 620957-92-8 4-{[(1S,2R)-2-({(tert-butoxycarbonyl)amino[(tert-butoxycarbonyl)imino]methyl}amino)cyclohexyl]amino}-N-(4-methoxyphenyl)-6-methylquinazoline-2-carboxamide 
• 620957-97-3 4-{[(1S,2R)-2-({(tert-butoxycarbonyl)amino[(tert-butoxycarbonyl)imino]methyl}amino)cyclohexyl]amino}-N-isobutyl-6-methylquinazoline-2-carboxamide 
• 620957-88-2 4-{[(1S,2R)-2-({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)cyclohexyl]amino}-6-methylquinazoline-2-carboxylic acid ethyl ester 
• 620957-82-6 4-{[(1S,2R)-2-({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)cyclohexyl]amino}-6-methylquinazoline-2-carboxylic acid 
• 1123685-30-2 N-[(1R,2S)-2-((2-[(4-chlorophenyl)carbonyl]amino-6-methylquinazolin-4-yl)amino)cyclohexyl]-N',N-bis(tert-butoxycarbonyl)guanidine 
• 620957-75-7 N-((1R,2S)-2-[(2-amino-6-methylquinazolin-4-yl)-amino]cyclohexyl)-N',N''-bis(tert-butoxycarbonyl)guanidine 
• 620957-79-1 tert-butyl [(1R,2S)-2-((2-[(4-methoxybenzyl)amino]-6-methylquinazolin-4-yl)amino)cyclohexyl]carbamate 
• 620957-80-4 (1R,2S)-2-[(2-amino-6-methylquinazolin-4-yl)amino]-cyclohexylamine 

Relevant articles and documents

CYCLOHEXANEDIAMINE COMPOUNDS AND METHODS FOR THEIR PREPARATION

The present invention provides processes for the preparation of cyclohexanediamine compounds of formula Ia and intermediates thereof. The compounds are useful as Syk kinase inhibitors and in various pharmaceutical compositions, and particularly useful for treating conditions mediated at least in part by Syk kinase activity.

Novel Compounds

Compounds of Formulae I, or pharmaceutically acceptable salts thereof: wherein A1, A2, G1, G2 G3, R1, R2, X, Y, Z, m, n and p are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

(1S,2R/1R,2S)-aminocyclohexyl glycyl thymine PNA: Synthesis, monomer crystal structures, and DNA/RNA hybridization studies

(Matrix Presented) The synthesis of ethyl cis-(1s,2R/1R,2S)-2.aminocyclohex-1-yI-N-(thymin-1-yl-acetyl) glycinate (10a and 10b) via enzymatic resolution of the key racemic intermediate trans-2-azido cyclohexanols 3 is reported. The crystal structures of 10 show equatorial disposition of the tertiary amide group, with the torsion angle β in the range 60-70°. The PNA oligomers incorporating these show differential effects in hybridizing with complementary DNA and RNA.