26008-87-7Relevant academic research and scientific papers
(2-Phenyl-[1,3,2]dithiarsolan-4-yl)-methanol derivatives show in vitro antileukemic activity
Gibaud, Stéphane,Alfonsi, Rapha?l,Mutzenhardt, Pierre,Fries, Isabelle,Astier, Alain
, p. 1081 - 1084 (2006)
The antileukemic activity of a series of (2-Phenyl-[1,3,2]dithiarsolan-4- yl)-methanol derivatives was tested on K562 and U937 human leukemia cell lines. Their systemic toxicity was estimated by the corresponding LD50 on mice. The cytotoxic activity of each derivative was significantly better than that of arsenic trioxide and the therapeutic index (T.I. = LD 50/IC50) was improved. No correlation between log P and the activity or the toxicity was found.
2D NMR Studies of the Phenyldichloroarsine-British Anti-Lewisite Adduct
Dill, Kilian,Adams, Earle R.,O'Connor, Richard J.,McGown, Evelyn L.
, p. 1074 - 1077 (1987)
One- and two-dimensional NMR spectroscopy was used to determine the structure of the phenyldichloroarsine-British anti-lewisite adduct.The major component had the hydroxymethyl group in the anti orientation with respect to the phenyl ring on the arsenous atom.This structure was based on the chemical shifts of the 1H and 13C resonances and on the respective homonuclear coupling constants.KEY WORDS - 2D NMR Phenyldichloroarsine-British anti-lewisite adduct Structural isomerism
