(2-Phenyl-[1,3,2]dithiarsolan-4-yl)-methanol derivatives show in vitro antileukemic activity

Article abstract of DOI:10.1016/j.jorganchem.2005.11.007

The antileukemic activity of a series of (2-Phenyl-[1,3,2]dithiarsolan-4- yl)-methanol derivatives was tested on K562 and U937 human leukemia cell lines. Their systemic toxicity was estimated by the corresponding LD₅₀ on mice. The cytotoxic activity of each derivative was significantly better than that of arsenic trioxide and the therapeutic index (T.I. = LD ₅₀/IC₅₀) was improved. No correlation between log P and the activity or the toxicity was found.