26028-68-2

Basic information

• Product Name: 5-(2,4-DICHLORO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL
• Synonyms: 3H-1,2,4-Triazole-3-thione,5-(2,4-dichlorophenyl)-1,2-dihydro-;5-(2,4-dichlorophenyl)-1,2-dihydro-3H-[1,2,4]-Triazol-3-thione
• CAS NO: 26028-68-2
• Molecular Formula: C₈H₅Cl₂N₃S
• Molecular Weight: 246.1164
• Mol File: 26028-68-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 330.7°Cat760mmHg
• Flash Point: 153.8°C
• Appearance: /
• Density: 1.68g/cm³
• Vapor Pressure: 0.000164mmHg at 25°C
• Refractive Index: 1.76
• CAS DataBase Reference: 5-(2,4-DICHLORO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2,4-DICHLORO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL(26028-68-2)
• EPA Substance Registry System: 5-(2,4-DICHLORO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL(26028-68-2)

Safety Data

• Hazardous Substances Data: 26028-68-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H5Cl2N3S/c9-4-1-2-5(6(10)3-4)7-11-8(14)13-12-7/h1-3H,(H2,11,12,13,14)

Upstream product

• 79-19-6 thiosemicarbazide 
• 89-75-8 2,4-dichlorobenzoyl chloride 
• 26036-09-9 1-(2,4-dichlorobenzoyl)-3-thiosemicarbazide 
• 50-84-0 2,4 dichlorobenzoic acid 
• 56882-52-1 ethyl 2,4-dichlorobenzoate 
• 5814-06-2 2,4-dichlorobenzohydrazide 

Downstream Products

• 134886-49-0 2-(2,4-Dichloro-phenyl)-5-[1-phenyl-meth-(Z)-ylidene]-thiazolo[3,2-b][1,2,4]triazol-6-one 
• 134886-50-3 2-(2,4-Dichloro-phenyl)-5-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-thiazolo[3,2-b][1,2,4]triazol-6-one 
• 134886-48-9 7-carbomethoxy-2-(2,4-dichlorophenyl)-7H-<1,2,4>triazolo<3,2-b><1,3>thiazine-7-one 
• 1351946-12-7 C₁₂H₁₄Cl₂N₄S 
• 1351946-13-8 C₁₄H₁₈Cl₂N₄S 
• 1351946-14-9 C₂₂H₃₀Cl₂N₄S 
• 111827-86-2 2,6-Bis-(2,4-dichloro-phenyl)-thiazolo[3,2-b][1,2,4]triazole 
• 111827-87-3 6-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-thiazolo[3,2-b][1,2,4]triazole 
• 111827-85-1 6-(4-Bromo-phenyl)-2-(2,4-dichloro-phenyl)-thiazolo[3,2-b][1,2,4]triazole 
• 111827-75-9 5-Phenylthiazolo<3,2-b>-2-(2,4-dichlorophenyl)-1,2,4-triazole 
• 134886-44-5 2-(2,4-dichlorophenyl)thiazolo<3,2-b><1,2,4>triazol-6(5H)-one 
• 93677-99-7 3-(2,4-Dichloro-phenyl)-4-methyl-5-methylsulfanyl-4H-[1,2,4]triazole 
• 111827-73-7 1-(4-Bromo-phenyl)-2-[5-(2,4-dichloro-phenyl)-2H-[1,2,4]triazol-3-ylsulfanyl]-ethanone 
• 111827-84-0 1-(4-Chloro-phenyl)-2-[5-(2,4-dichloro-phenyl)-2H-[1,2,4]triazol-3-ylsulfanyl]-ethanone 

Relevant articles and documents

Dammarane sapogenin derivative and preparation method and application thereof

The invention belongs to the technical field of medicines, and relates to a dammarane sapogenin derivative and a preparation method and application thereof. A series of dammarane sapogenin derivativesare obtained by combining dammarane sapogenins from plants with different groups. Anticancer activity evaluation and anticancer activity mechanism research are carried out on the derivative, and results show that the prepared dammarane sapogenin derivative has a remarkable anticancer effect, has no toxic effect on normal cells and can be used for preparing drugs for treating cancers.

Synthesis of N′-arylidene-2-(5-aryl-1H-1, 2, 4-triazol-3-ylthio) acetohydrazides as antidepressants

Abstract: A series of N′-arylidene-2-(5-aryl-1H-1, 2, 4-triazol-3-ylthio) acetohydrazide were synthesized. Condensation of aromatic aldehydes with 2-(5-aryl-1H-1, 2, 4-triazol-3-ylthio) acetohydrazide gave corresponding N′ -arylidene-2-(5-aryl-1H-1, 2, 4-triazol-3-ylthio) acetohydrazide. Spectral and elemental analysis was used for structural elucidation of novel 1, 2, 4-triazole schiff bases. The newly synthesized compounds were screened for their antidepressant activity by using tail suspension test in mice. Compound 4l showed significant activity among the series. Graphical Abstract: A series of new N′-arylidene-2-(5-aryl-1H-1, 2, 4-triazol-3-ylthio)acetohydrazide have been synthesized and characterized. The results revealed that compound 4l with bromo substitution exhibited promising antidepressant activity among the series. [InlineMediaObject not available: see fulltext.].

Synthesis and antidepressant activity of di substituted-5-Aryl-1,2,4- triazoles

A series of 5-Aryl-1H-1,2,4-triazole-3-thiol (3) were synthesized. Alkylation of thiol group with N,Ndimethyl/ diethyl/dicyclo hexyl-(2-chloro ethyl) amine gave compounds N,N-disubstituted-2-(5-Aryl-1H-1,2,4-triazol-3- ylthio)ethanamine (4). These compounds were characterized on the basis of IR, 1H NMR, Mass spectral data, and elemental analysis. The newly synthesized compounds were screened for their antidepressant activity by using tail suspension test in mice. Springer Science+Business Media, LLC 2011.