26036-09-9

Basic information

• Product Name: Benzoic acid, 2,4-dichloro-, 2-(aminothioxomethyl)hydrazide
• CAS NO: 26036-09-9
• Molecular Formula: C8H7Cl2N3OS
• Molecular Weight: 264.135
• Mol File: 26036-09-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2,4-dichloro-, 2-(aminothioxomethyl)hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2,4-dichloro-, 2-(aminothioxomethyl)hydrazide(26036-09-9)
• EPA Substance Registry System: Benzoic acid, 2,4-dichloro-, 2-(aminothioxomethyl)hydrazide(26036-09-9)

Safety Data

• Hazardous Substances Data: 26036-09-9(Hazardous Substances Data)

Upstream product

• 35112-28-8 methyl 2,4-dichlorobenzoate 
• 79-19-6 thiosemicarbazide 
• 89-75-8 2,4-dichlorobenzoyl chloride 
• 56882-52-1 ethyl 2,4-dichlorobenzoate 
• 50-84-0 2,4 dichlorobenzoic acid 
• 333-20-0 potassium thioacyanate 
• 67-64-1 acetone 
• 5814-06-2 2,4-dichlorobenzohydrazide 

Downstream Products

• 60160-13-6 2-amino-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole 
• 26028-68-2 3-(2,4-dichlorophenyl)-5-mercapto-1,2,4-1H-triazole 
• 28004-63-9 5-(2,4-dichloro-phenyl)-[1,3,4]thiadiazol-2-ylamine 
• 1351946-12-7 C₁₂H₁₄Cl₂N₄S 
• 1351946-13-8 C₁₄H₁₈Cl₂N₄S 
• 1351946-14-9 C₂₂H₃₀Cl₂N₄S 
• 26028-68-2 C₈H₅Cl₂N₃S 
• 26028-68-2 5-(2,4-dichloro-phenyl)-2,4-dihydro-[1,2,4]triazole-3-thione 
• 132407-84-2 1-(2,4-Dichloro-benzoyl)-3-[5-(2,4-dichloro-phenyl)-[1,3,4]thiadiazol-2-yl]-thiourea 
• 132407-81-9 1-(2,4-Dichloro-benzoyl)-3-[5-(2,4-dichloro-phenyl)-[1,3,4]oxadiazol-2-yl]-thiourea 
• 132407-90-0 2,5-Bis-(2,4-dichloro-phenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-7-thione 
• 132407-87-5 2,5-Bis-(2,4-dichloro-phenyl)-[1,3,4]oxadiazolo[3,2-a][1,3,5]triazine-7-thione 
• 132407-83-1 1-Benzoyl-3-[5-(2,4-dichloro-phenyl)-[1,3,4]thiadiazol-2-yl]-thiourea 
• 132407-80-8 1-Benzoyl-3-[5-(2,4-dichloro-phenyl)-[1,3,4]oxadiazol-2-yl]-thiourea 

Relevant articles and documents

Novel panaxadiol triazole derivatives induce apoptosis in HepG-2 cells through the mitochondrial pathway

In this study, we introduced 1, 2, 4-triazole groups into panaxadiol (PD) to obtain 18 panaxadiol triazole derivatives. Five cancer cells and one normal cell were evaluated for cytotoxicity by MTT assay. The results showed that most of the derivatives could inhibit cancer cell proliferation, and the anti-proliferative activity of compound A1 was the most significant. For HepG-2 cells, the IC50 value was 4.21 ± 0.54 μM, which was nearly 15 times higher than the activity of PD. Further studies showed that compound A1 could induce apoptosis in HepG-2 cells, and could enhance the expression of Cl-caspase-3, Cl-caspase-9 and Cl-PARP. Moreover, Western blot analysis showed that after treating HepG-2 cells with compound A1, the expression of p53 protein was increased and the ratio of Bax/Bcl-2 was gradually increased. The cytoplasmic Bax is then translocated to the mitochondria, causing the release of Cyt c protein. Therefore, the results indicate that compound A1 induces apoptosis through the mitochondrial pathway and can be used the potential to develop new anti-proliferative agents.

Synthesis and antidepressant activity of di substituted-5-Aryl-1,2,4- triazoles

A series of 5-Aryl-1H-1,2,4-triazole-3-thiol (3) were synthesized. Alkylation of thiol group with N,Ndimethyl/ diethyl/dicyclo hexyl-(2-chloro ethyl) amine gave compounds N,N-disubstituted-2-(5-Aryl-1H-1,2,4-triazol-3- ylthio)ethanamine (4). These compounds were characterized on the basis of IR, 1H NMR, Mass spectral data, and elemental analysis. The newly synthesized compounds were screened for their antidepressant activity by using tail suspension test in mice. Springer Science+Business Media, LLC 2011.

Synthesis and antibacterial activity of 1-(2,4-dichlorobenzoyl)-4-substituted thiosemicarbazides, 1,2,4-triazoles and their methyl derivatives

-