260353-13-7

Upstream product

• 108-32-7 1,2-propylene cyclic carbonate 
• 5122-94-1 4-biphenylboronic acid 
• 14823-09-7 6-iodopyridazin-3(2H)-one 
• 377047-49-9 6-biphenyl-3-chloropyridazine 
• 144432-80-4 2-(biphenyl-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 4845-49-2 1,3-diphenyl-5-oxo-4,5-dihydro-1H-pyrazole 
• 71149-96-7 β-(4-phenylbenzoyl)acrylic acid 

Downstream Products

• 88490-32-8 (6-biphenyl-4-yl-pyridazin-3-yl)-hydrazine 
• 377047-49-9 6-biphenyl-3-chloropyridazine 

Relevant academic research and scientific papers

Scope and limitation of propylene carbonate as a sustainable solvent in the Suzuki-Miyaura reaction

The Suzuki-Miyaura reaction is one of the most used transformations in drug research. Thus making this reaction more sustainable is of considerable current interest. Here we show that propylene carbonate (PC) can be used as a solvent for the Suzuki-Miyaura reaction. PC is one of the greenest solvents since it is synthesized under green conditions by the use of carbon dioxide in the air. All reactions proceeded well and good or excellent yields were observed for the biaryl products. Nonetheless in the case of pyridazinones, 2-hydroxypropyl- chain containing side-products were observed. Importantly, this fact allowed the isolation of several novel compounds which were generated under prominently green conditions.

Pyridazinone derivatives and preparation method thereof, and organic electroluminescent device

The invention discloses pyridazinone derivatives and a preparation method thereof, and an organic electroluminescent device. The pyridazinone derivatives have structures as shown in a formula (1) or (2) which is described in the specification. In the formulas, Ar1 and Ar2 are substituted or unsubstituted arylidene groups independently; R1 and R2 are independently selected from the group consistingof hydrogen, alkyl groups having 1-8 carbon atoms, a cyano group, aryl groups having 6 to 40 carbon atoms or heteroaryl groups having 2 to 40 carbon atoms, an amino group, and -NR3R4; R3 and R4 are substituted or unsubstituted aryl groups independently; and m, n and k are independently selected from the group consisting of 1, 2 and 3. The pyridazinone derivatives have good electron transport andhole blocking properties and can be used as an electron transport material or hole blocking material in the organic electroluminescent element.

Some reactions with 6-(biphenyl)-4-(5-oxo-1,3-diphenyl-2-pyrazolin-4-yl)-4,5-dihydropyridazin-3-(2H) ones

4-biphenyl-4-oxo-2-butenoic acid (1) reacted with 1,3-diphenyl-2-pyrazolin-5-one (2) to give 4-biphenyl-4-oxo-2-(5-oxo-1,3-diphenyl-2-pyrazolin-4-yl) butanoic acid (3) The condensation of (3) with hydrazines affords the corresponding pyridazinones (4, 5). Reaction of pyridazinone (4) with POCl3 gave the chloropyridazine derevative (7) which was subjected to further studies with hydrazine hydrate, aromatic amines, anthranilic acid, thiourea and sulfa drugs to give compounds (8-15). Reaction of pyridazinone (4) with phosphorus pentasulfide gave the corresponding thiopyridazine derivative (16). The in-vitro antibacterial screening revealed that some of the new compounds possess activity against Gram-positive, Gram-negative bacteria and fungi.