377047-49-9Relevant academic research and scientific papers
Construction of Vesicles, Micro/Nanorods and Ultralong Nanotubes through the Self-Assembly of Non-Classical Amphiphiles with Rigid Conformation
Lin, Feng,Liang, Rongran,Qi, Qiaoyan,Zhan, Tianguang,Li, Zhanting,Zhao, Xin
, p. 429 - 434 (2017)
Amphiphilic molecules have long been regarded as an important class of supramolecular building blocks for the fabrication of nanomaterials. While most previous researches have mainly focused on amphiphlies with flexible structures, in this work, four novel amphiphiles possessing wholly-rigid skeletons have been designed and synthesized. These molecules were built by using 4,4’-bipyridin-1-ium or viologen as hydrophilic moieties and phenyl or biphenyl as hydrophobic segments, bridged by a pyridazine unit. Their self-assembly behavior has been investigated by scanning electron microscopy (SEM), atomic force microscopy (AFM) and transmission electron microscopy (TEM), which revealed they could self-assemble into well-ordered nanoarchitectures with various morphologies such as vesicles, micro/nanorods and nanotubes in water or methanol, depending on their hydrophilic/hydrophobic fraction ratios.
Pyridazinone derivatives and preparation method thereof, and organic electroluminescent device
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Paragraph 0104-0106, (2018/09/28)
The invention discloses pyridazinone derivatives and a preparation method thereof, and an organic electroluminescent device. The pyridazinone derivatives have structures as shown in a formula (1) or (2) which is described in the specification. In the formulas, Ar1 and Ar2 are substituted or unsubstituted arylidene groups independently; R1 and R2 are independently selected from the group consistingof hydrogen, alkyl groups having 1-8 carbon atoms, a cyano group, aryl groups having 6 to 40 carbon atoms or heteroaryl groups having 2 to 40 carbon atoms, an amino group, and -NR3R4; R3 and R4 are substituted or unsubstituted aryl groups independently; and m, n and k are independently selected from the group consisting of 1, 2 and 3. The pyridazinone derivatives have good electron transport andhole blocking properties and can be used as an electron transport material or hole blocking material in the organic electroluminescent element.
Synthesis, antitubercular, antifungal and antibacterial activities of 6-substituted phenyl-2-(3′-substituted phenyl pyridazin-6′-yl)-2,3, 4,5-tetrahydropyridazin-3-one
Islam, Mojahidul,Siddiqui, Anees A.,Rajesh, Ramadoss
experimental part, p. 353 - 362 (2009/04/11)
A series of 6-substituted phenyl-2-(3′-substituted phenyl pyridazin-6′-yl)-2,3,4,5-tetrahydropyridazin-3-ones has been synthesized. An appropriate aromatic hydrocarbon reacts with succinic anhydride in presence of AlCl3 to yield β-aroyl propionic acid. The corresponding acid was cyclized with hydrazine hydrate to give 6-(substituted aryl)-2,3,4,5- tetrahydro-3-pyridazinone, which was heated on steam bath with phosphorus( V) oxychloride to yield 3-chloro 6-substituted phenyl pyridazine. This intermediate after reaction with hydrazine hydrate was converted into 3-hydrazino-6- substituted phenyl pyridazine. The resulting product was converted into 6-substituted phenyl-2-(3′-substituted phenyl pyridazin-6′-yl)-2,3, 4,5-tetrahydropyridazin-3-one by reacting with substituted aroyl propionic acid. Spectral data (IR, NMR, mass spectra) confirmed the structures of the synthesized compounds. The synthesized compounds were investigated for their in vitro antitubercular, antifungal and antibacterial activities. The results indicated that the synthesized compounds have mild to potent activities with reference to their appropriate reference standards.
NOVEL USE OF TRICYCLIC COMPOUND
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Page/Page column 14; 16; 19, (2008/06/13)
Pharmaceutical compositions for enhancing the expression of apoAI are provided, which are used as medicaments for treatment of cardiovascular diseases on the basis of improving the functions of HDL.Pharmaceutical compositions for enhancing the expression of apoAI which comprises a compound of formula (I): in which X1 and X2 are independently an aryl or heteroaryl that may be optionally substituted, a hydrogen, a halogen, or the like; ring A is a benzene ring or 6-membered aromatic heterocyclic ring containing 1 to 3 N atoms that may be optionally condensed with another aromatic ring; R1 to R4 are independently a hydrogen, a halogen, a lower alkyl, a lower alkoxy or the like; a prodrug thereof, a pharmaceutically acceptable salt or solvate of them are disclosed.
Some reactions with 6-(biphenyl)-4-(5-oxo-1,3-diphenyl-2-pyrazolin-4-yl)-4,5-dihydropyridazin-3-(2H) ones
Kassab,Sayed,Radwan,Abd El-Azzez
, p. 649 - 655 (2007/10/03)
4-biphenyl-4-oxo-2-butenoic acid (1) reacted with 1,3-diphenyl-2-pyrazolin-5-one (2) to give 4-biphenyl-4-oxo-2-(5-oxo-1,3-diphenyl-2-pyrazolin-4-yl) butanoic acid (3) The condensation of (3) with hydrazines affords the corresponding pyridazinones (4, 5). Reaction of pyridazinone (4) with POCl3 gave the chloropyridazine derevative (7) which was subjected to further studies with hydrazine hydrate, aromatic amines, anthranilic acid, thiourea and sulfa drugs to give compounds (8-15). Reaction of pyridazinone (4) with phosphorus pentasulfide gave the corresponding thiopyridazine derivative (16). The in-vitro antibacterial screening revealed that some of the new compounds possess activity against Gram-positive, Gram-negative bacteria and fungi.
