260354-12-9

Basic information

• Product Name: 3-CHLORO-1-(2-THIENYL)-1-PROPANOL
• Synonyms: ALFA-(2-CHLOROETHYL)-2-THIOPHENEMETHANOL;ALFA-(2-CHLOROEHTYL)-2-THIOHENEMETHANOL;alpha-(2-Chloroehtyl)-2-thiophenemethanol;3-Chlofo-1-(2-thienyl)-1-propanol;3-Chloro-1-(thiophen-2-yl)propan-1-ol;alpha-(2-Chloroethyl)-2-thiophenemethanol
• CAS NO: 260354-12-9
• Molecular Formula: C₇H₉ClOS
• Molecular Weight: 176.66
• Mol File: 260354-12-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 308.473 °C at 760 mmHg
• Flash Point: 140.36 °C
• Appearance: /
• Density: 1.281 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: 3-CHLORO-1-(2-THIENYL)-1-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-1-(2-THIENYL)-1-PROPANOL(260354-12-9)
• EPA Substance Registry System: 3-CHLORO-1-(2-THIENYL)-1-PROPANOL(260354-12-9)

Safety Data

• Hazardous Substances Data: 260354-12-9(Hazardous Substances Data)

Usage

General Description

3-Chloro-1-(2-thienyl)-1-propanol is a chemical compound with the molecular formula C7H9ClOS. It is a colorless to light yellow liquid with a molecular weight of 168.66 g/mol. 3-CHLORO-1-(2-THIENYL)-1-PROPANOL is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a building block in organic synthesis, particularly in the production of chiral compounds. Additionally, 3-Chloro-1-(2-thienyl)-1-propanol is utilized as a reagent in the chemical industry for the manufacture of various products. Its primary applications include its use as a biochemical and in chemical research. This chemical is known for its ability to undergo various chemical reactions, making it a versatile and important compound in the chemical industry.

InChI:InChI=1/C7H9ClOS/c8-4-3-6(9)7-2-1-5-10-7/h1-2,5-6,9H,3-4H2

Upstream product

• 40570-64-7 3-chloro-1-(2-thienyl)propan-1-one 

Downstream Products

• 116539-56-1 3-(methylamino)-1-(thiophen-2-yl)propan-1-ol 
• 1151818-12-0 2-[(3-chloro-1-thien-2-ylpropoxy) carbonyl] benzoic acid 

Relevant articles and documents

Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for depression

Compounds possessing more than one functional activity incorporated into the same molecule may have advantages in treating complex disease states. Balanced serotonin/norepinephrine reuptake inhibitors (SNRIs) (i.e., (R)- and (S)-norduloxetine) were chemically linked to a PDE4 inhibitor via a five carbon bridge. The new dual SNRI/PDE4 inhibitors (i.e., (R)-15 and (S)-15) showed moderately potent serotonin reuptake inhibition (IC50 values of 442 and 404 nM, respectively) but low reuptake inhibition of norepinephrine (IC50 values of 2097 and 2190 nM, respectively) in vitro. The dual SNRI/PDE4 inhibitors (i.e., (R)-15 and (S)-15) also inhibited PDE4D2 (i.e., Ki values of 23 and 45 nM, respectively). Due to their synergistic functional activity, SNRI/PDE4 inhibitors may be effective in treating diseases such as depression.

COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN

The present invention relates to a compound of formula (I): wherein the meanings for the various substituents are as disclosed in the description, having dual pharmacological activity towards both the α2δ subunit, in particular the α2δ- 1 subunit, of the voltage-gated calcium channel and the NET receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

OLIGOMER-ARYLOXY-SUBSTITUTED PROPANAMINE CONJUGATES

The invention relates to (among other things) oligomer- aryloxy-substituted propanamine conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over un-conjugated aryloxy-substituted propanamine compounds.