260391-07-9

Upstream product

• 107-13-1 acrylonitrile 
• 249617-46-7 (-)-(S)-[Diphenyl(tert-butyldimethylsilyloxy)methyl]pyrrolidin-2-one 
• 4931-66-2 methyl (S)-pyroglutamate 
• 149561-81-9 (-)-(S)-5-(Hydroxydiphenylmethyl)pyrrolidin-2-one 
• 69739-34-0 t-butyldimethylsiyl triflate 

Downstream Products

• 260391-08-0 1-(3-amino-propyl)-5-[(tert-butyl-dimethyl-silanyloxy)-diphenyl-methyl]-pyrrolidin-2-one 
• 260391-11-5 tert-butyl (3-[(2S)-(hydroxydiphenylmethyl)-5-thioxopyrrolidin-1-yl]propyl)carbamate 
• 260391-09-1 tert-butyl (3-{(2S)-[(tert-butyldimethylsilyloxy)diphenylmethyl]-5-oxopyrrolidin-1-yl}propyl)carbamate 
• 260391-10-4 tert-butyl (3-{(2S)-[(tert-butyldimethylsilyloxy)diphenylmethyl]-5-thioxopyrrolidin-1-yl}propyl)carbamate 

Relevant academic research and scientific papers

(S)-Pyroglutamic acid, (S)-malic acid, and (S)-serine as useful starting materials in the synthesis of enantiopure hydroxyamidines

The synthesis of four enantiopure hydroxyamidines is described. One amidine was obtained from (S)-pyroglutamic acid. Its key step involved the addition of phenylmagnesium bromide to the corresponding ester, affording the tertiary alcohol without detectabl