3-{(2S)-[(tert-butyldimethylsilyloxy)diphenylmethyl]-5-oxopyrrolidin-1-yl}propionitrile

Base Information

Chemical Name:3-{(2S)-[(tert-butyldimethylsilyloxy)diphenylmethyl]-5-oxopyrrolidin-1-yl}propionitrile
CAS No.:260391-07-9
Molecular Formula:C₂₆H₃₄N₂O₂Si
Molecular Weight:434.654
Hs Code.:

Synonyms:3-{(2S)-[(tert-butyldimethylsilyloxy)diphenylmethyl]-5-oxopyrrolidin-1-yl}propionitrile

Suppliers and Price of 3-{(2S)-[(tert-butyldimethylsilyloxy)diphenylmethyl]-5-oxopyrrolidin-1-yl}propionitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-{(2S)-[(tert-butyldimethylsilyloxy)diphenylmethyl]-5-oxopyrrolidin-1-yl}propionitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-{(2S)-[(tert-butyldimethylsilyloxy)diphenylmethyl]-5-oxopyrrolidin-1-yl}propionitrile

There total 5 articles about 3-{(2S)-[(tert-butyldimethylsilyloxy)diphenylmethyl]-5-oxopyrrolidin-1-yl}propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 107-13-1,25014-41-9
acrylonitrile

: 249617-46-7
(-)-(S)-[Diphenyl(tert-butyldimethylsilyloxy)methyl]pyrrolidin-2-one

: 260391-07-9
3-{(2S)-[(tert-butyldimethylsilyloxy)diphenylmethyl]-5-oxopyrrolidin-1-yl}propionitrile

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 3.5h;
DOI:10.1002/(sici)1099-0690(200001)2000:1<115::aid-ejoc115>3.0.co;2-j

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 260391-07-9
3-{(2S)-[(tert-butyldimethylsilyloxy)diphenylmethyl]-5-oxopyrrolidin-1-yl}propionitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / 2,6-lutidine / CH₂Cl₂ / 22 h / 20 °C

2: 100 percent / NaOH / tetrahydrofuran / 3.5 h / 20 °C

With 2,6-dimethylpyridine; sodium hydroxide; In tetrahydrofuran; dichloromethane; 1: Substitution / 2: Addition;
DOI:10.1002/(sici)1099-0690(200001)2000:1<115::aid-ejoc115>3.0.co;2-j

Reference yield:

: phenylmagnesium bromide

: 260391-07-9
3-{(2S)-[(tert-butyldimethylsilyloxy)diphenylmethyl]-5-oxopyrrolidin-1-yl}propionitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / diethyl ether; tetrahydrofuran / 1.25 h / -78 - 0 °C

2: 100 percent / 2,6-lutidine / CH₂Cl₂ / 22 h / 20 °C

3: 100 percent / NaOH / tetrahydrofuran / 3.5 h / 20 °C

With 2,6-dimethylpyridine; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; 1: Substitution / 2: Substitution / 3: Addition;
DOI:10.1002/(sici)1099-0690(200001)2000:1<115::aid-ejoc115>3.0.co;2-j