260392-65-2

Usage

Uses

Used in Scientific Research:
Trans-2-Methylamino-cyclohexanol hydrochloride is used as a research chemical for various scientific applications. Its role in research can vary widely depending on the specific scientific or industrial application, making it a versatile compound for exploration and experimentation in the field of chemistry and related disciplines.
Used in Laboratory Settings:
In laboratory settings, trans-2-Methylamino-cyclohexanol hydrochloride is used as a reagent or a precursor in the synthesis of other compounds. Its availability as a hydrochloride salt facilitates its use in various chemical reactions, contributing to the advancement of chemical research and development.
Used in Industrial Applications:
Trans-2-Methylamino-cyclohexanol hydrochloride may also find use in industrial applications, where its unique properties can be harnessed for the production of specific products or processes. The exact function or use in these applications can vary, but its presence as a chemical intermediate or catalyst can be significant in the development of new materials or technologies.

InChI:InChI=1/C7H15NO.ClH/c1-8-6-4-2-3-5-7(6)9;/h6-9H,2-5H2,1H3;1H/t6-,7-;/m1./s1

Upstream product

• 112708-86-8 (1S,2S)-trans-2-(N-benzoyl-N-methyl)amino-1-cyclohexanol 
• 112708-85-7 trans-2--cyclohexanol 
• 20431-81-6 rac-trans-2-methylamino-cyclohexanol 

Relevant academic research and scientific papers

Synthesis and conformational study of stereoisomeric 2-phenyl-4a,5,6,7,8,8a-hexahydro-4H-1,3,4-benzoxadiazines

The synthesis and conformational behaviour of some new cis- and trans-fused N4-R-2-phenyl-4a,5,6,7,8,8a-hexahydro-4H-1,3,4-benzoxadiazines are described. Their vicinal coupling constants reveal that the trans-fused isomers adopt an anancomeric chair-(half-chair) conformation, whereas the cis-fused isomers exist in a conformational equilibrium of the O-in (having the oxygen attached axially to the cyclohexyl ring) and O-out conformers. At room temperature, the O-in conformers slightly predominate, as estimated from the vicinal coupling constants. However, only a rough estimation, especially in the cis N-CH2Ph derivative 9a, can be made of the conformational equilibria due to an obvious deformation of the carbocyclic ring (a flattened, non-ideal chair conformation), making the selection of model 3JH,H values difficult. At 193 K the O-in conformer predominates in a ratio of 85:15 for the cis N-CH2Ph derivative and 70:30 for the cis N-Me derivative, estimated from the 13C signal integrals of both cis conformers, as they separated in low-temperature experiments (193 K).

O.N-Bis(diphenylphosphino) Derivatives of Chiral trans- and cis-2-Aminocyclohexanols: Synthesis and Enantioselective Behaviour as Ligands in Rh-based Homogeneous Hydrogenation Catalysts

trans- and cis-2-Methylamino cyclohexanols (MAC) were prepared in enantiomerically pure forms and transformed into O.N-bis(diphenylphosphino) derivatives ("PONP").An analogous trans-1R;2R-aminocyclohexanol PONP could only be isolated in an impure form, whereas the attempted synthesis of PONP's of diastereomeric trans-2-(N-α-phenylethylamino)-cyclohexanols failed.Cationic Rh(I)-chelates of the new PONP's catalyzed the enantioselective hydrogenation of dehydro-α-acylamino acids with /= 97percent ee.A comparison of the enantiodiscriminating properties of the MAC-PONP's with structurally related chiral ligands leads to surprising conclusions.