20431-81-6

Basic information

• Product Name: 2-METHYLAMINO-CYCLOHEXANOL
• Synonyms: 2-METHYLAMINO-CYCLOHEXANOL;trans-2-Methylamino-cyclohexanol;2-(MethylaMino)cyclohexan-1-ol;2-Methylamino-1-Cyclohexanol;Nsc245089;Cyclohexanol, 2-(methylamino)-;(1S,2S)-2-(methylamino)cyclohexan-1-ol
• CAS NO: 20431-81-6
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.2001
• Mol File: 20431-81-6.mol
• Article Data: 14

Chemical Properties

• Melting Point: 24-25 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 211.7°C at 760 mmHg
• Flash Point: 86.8°C
• Appearance: /
• Density: 0.97g/cm³
• Vapor Pressure: 0.0404mmHg at 25°C
• Refractive Index: 1.479
• Storage Temp.: 2-8°C(protect from light)
• PKA: 15.03±0.40(Predicted)
• CAS DataBase Reference: 2-METHYLAMINO-CYCLOHEXANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYLAMINO-CYCLOHEXANOL(20431-81-6)
• EPA Substance Registry System: 2-METHYLAMINO-CYCLOHEXANOL(20431-81-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 20431-81-6(Hazardous Substances Data)

Usage

General Description

2-Methylamino-cyclohexanol, also known as 2-phenylamino-cyclohexanol, is a chemical compound with the molecular formula C7H15NO. It is a secondary amine and cycloalkanol, commonly used as a precursor in the synthesis of active pharmaceutical ingredients. It is also used as an intermediate in the production of various substances, including dyes, pigments, and pesticides. 2-METHYLAMINO-CYCLOHEXANOL is known for its ability to interact with receptors in the central nervous system, and its potential for use in developing medications for conditions such as pain and neurological disorders. However, it has limited research available on its specific properties and uses, and caution should be taken when handling and using this chemical due to its potential health hazards.

InChI:InChI=1/C7H15NO/c1-8-6-4-2-3-5-7(6)9/h6-9H,2-5H2,1H3

Upstream product

• 286-20-4 cyclohexane-1,2-epoxide 
• 74-89-5 methylamine 
• 6628-80-4 trans-2-chlorocyclohexanol 
• 83152-97-0 trans-2-isocyano-1-cyclohexanol 
• 83152-87-8 trans-2-(trimethylsiloxy)cyclohexyl isocyanide 
• 24796-87-0 2-bromo-cyclohexanol 
• 286-20-4 cyclohexene oxide 
• 931-16-8 (+/-)-trans-2-aminocyclohexanol 
• 121282-70-0 (+/-)-trans-1-hydroxy-2-tert-butoxycarbonylamino-cyclohexane 
• 38898-70-3 cis-2-amino-cyclohexanol-⁽¹⁾ 
• 80-48-8 methyl p-toluene sulfonate 

Downstream Products

• 21651-83-2 (1R,2R)-trans-2-(N-methyl)amino-1-cyclohexanol 
• 21651-84-3 trans-2-(methylamino)cyclohexanol 
• 20431-81-6 cis-2-(N-methyl)amino-1-cyclohexanol 
• 23755-31-9 (+/-)-N-(trans-2-hydroxy-cyclohexyl)-N-methyl-benzamide 
• 90227-79-5 trans-(2-Hydroxy-cyclohexyl)-methylaminomethan-sulfonsaeure 
• 90227-79-5 cis-(2-Hydroxy-cyclohexyl)-methyl-aminomethan-sulfonsaeure 
• 87767-70-2 1-(2-chloroethyl)-3-(trans-2-hydroxycyclohexyl)-3-methylurea 
• 83196-12-7 trans-2-cyclohexanol 
• 116203-82-8 N-nitrosomethyl-N-2-oxocyclohexylamine 
• 218964-40-0 trans-2-(1-methylhydrazino)-1-cyclohexanol 
• 882409-15-6 (1R,2S)-cis-2-(N-methyl)amino-1-cyclohexanol 
• 112708-89-1 (1S,2R)-cis-2-(N-methyl)amino-1-cyclohexanol 

Relevant articles and documents

An efficient synthesis of enantiomerically pure trans-N1,N 2-dimethylcyclohexane-1,2-diamine

A new pathway is described to produce a highly optically pure isomer of trans-N1,N2-dimethylcyclohexane-1,2-diamine through four simple steps. Reaction of cyclohexene oxide with aqueous methylamine, followed by cyclisation with Mitsunobu reagent and ring-opening reactions gave rac-trans-N1,N2-dimethylcyclohexane-1,2-diamine, and the enantiomers were obtained via a kinetic resolution using tartaric acid.

M-Type SrFe12O19Ferrite: An Efficient Catalyst for the Synthesis of Amino Alcohols under Solvent-Free Conditions

Magnetically separable strontium hexaferrite SrFe12O19 was prepared using the chemical coprecipitation method, and the nanostructured material was characterized by X-ray diffraction, scanning electron microscopy (SEM), energy-dispersive spectrometry (EDS), and BET analysis. The SEM images showed the homogeneity of the chemical composition of SrFe12O19 and uniform distribution of size and morphology. The pore size of the nanomaterial and its specific area were determined by BET measurements. Strontium hexaferrite SrFe12O19 exhibited a strong magnetic field, which is highly suitable in the heterogeneous catalysis as it can be efficiently separated from the reaction. The magnetic nanocatalyst showed high activity and environmentally benign heterogeneous catalysts for the epoxide ring-opening with amines affording β-amino alcohols under solvent-free conditions. When unsymmetrical epoxides were treated in the presence of aromatics amines, the regioselectivity was influenced by the electronic and steric factors. Total regioselectivity was observed for the reactions performed with aliphatic amines. The magnetically SrFe12O19 nanocatalyst showed excellent recyclability with continuously good catalytic activities after four cycles.

Nickel-Catalyzed Intramolecular C?O Bond Formation: Synthesis of Cyclic Enol Ethers

An efficient and exceptionally mild intramolecular nickel-catalyzed carbon–oxygen bond-forming reaction between vinyl halides and primary, secondary, and tertiary alcohols has been achieved. Zinc powder was found to be an essential additive for obtaining