2604-08-2

Basic information

• Product Name: N,N-DIMETHYL-N-{4-[2-NITROVINYL]PHENYL}AMINE
• Synonyms: N,N-DIMETHYL-N-{4-[2-NITROVINYL]PHENYL}AMINE;N,N-Dimethyl-4-(2-nitrovinyl)aniline
• CAS NO: 2604-08-2
• Molecular Formula: C₁₀H₁₂N₂O₂
• Molecular Weight: 192.21448
• Mol File: 2604-08-2.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 336.6°Cat760mmHg
• Flash Point: 157.4°C
• Appearance: /
• Density: 1.167g/cm³
• Vapor Pressure: 0.000111mmHg at 25°C
• Refractive Index: 1.62
• CAS DataBase Reference: N,N-DIMETHYL-N-{4-[2-NITROVINYL]PHENYL}AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIMETHYL-N-{4-[2-NITROVINYL]PHENYL}AMINE(2604-08-2)
• EPA Substance Registry System: N,N-DIMETHYL-N-{4-[2-NITROVINYL]PHENYL}AMINE(2604-08-2)

Safety Data

• Hazardous Substances Data: 2604-08-2(Hazardous Substances Data)

Usage

General Description

N,N-Dimethyl-N-{4-[2-nitrovinyl]phenyl}amine is a chemical compound with the molecular formula C11H13N3O2. It is a yellow, crystalline solid that is mainly used in research and development as a building block for the synthesis of various pharmaceuticals and organic compounds. The compound contains a dimethylamine group and a nitrovinylphenyl group, which give it unique properties and reactivity. It is primarily utilized in organic synthesis for the modification of chemical structures and the creation of new compounds with potential pharmaceutical applications. Additionally, it is important to handle this chemical with care as it can be harmful if ingested or inhaled and may cause skin and eye irritation.

InChI:InChI=1/C10H12N2O2/c1-11(2)10-5-3-9(4-6-10)7-8-12(13)14/h3-8H,1-2H3/b8-7+

Upstream product

• 135711-32-9 [4-(1-Butylamino-2-nitro-ethyl)-phenyl]-dimethyl-amine 
• 75-52-5 nitromethane 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 102-96-5 (2-nitroethenyl)benzene 
• 100-52-7 benzaldehyde 
• 889-37-2 N,N-dimethyl-4-((phenylimino)methyl)aniline 

Downstream Products

• 92774-89-5 2-[1-(4-Dimethylamino-phenyl)-2-nitro-ethyl]-3-hydroxy-cyclopent-2-enone 
• 23630-92-4 1,1-dimethylamino-4-(2-nitroethyl)benzene 
• 1100256-72-1 (1R,2S,5R,8S)-5-((R)-1-(4-(N,N-dimethylamino)phenyl)-2-nitroethyl)-1,11,11-trimethyl-3-oxa-6-azatricyclo[6.2.1.0(2,7)]undec-6-en-4-one 
• 1100256-53-8 (1S,2R,5S,8R)-5-((S)-1-(4-(N,N-dimethylamino)phenyl)-2-nitroethyl)-8,11,11-trimethyl-3-oxa-6-azatricyclo[6.2.1.0(2,7)]undec-6-en-4-one 
• 1133892-37-1 4-(1,1,1-tribromo-3-nitropropan-2-yl)-N-N-dimethylbenzenamine 
• 1133892-53-1 4-(1,1-dibromo-3-nitroprop-1-en-2-yl)-N,N-dimethylbenzenamine 
• 1165944-60-4 (S)-4-(4-(dimethylamino)phenyl)-5-nitropentan-2-one 
• 1160841-00-8 (R)-4-(4-(dimethylamino)phenyl)-5-nitropentan-2-one 
• 1190132-36-5 2-((Z)-2-(4-(dimethylamino)phenyl)-1-nitrovinyl)-2-hydroxy-2H-indene-1,3-dione 
• 1190132-29-6 C₁₄H₁₅F₃N₂O₅ 
• 1190132-32-1 diethyl 2-((E)-2-(4-(dimethylamino)phenyl)-1-nitrovinyl)-2-hydroxymalonate 
• 942149-09-9 (S)-2-((R)-2-nitro-1-(4-dimethylaminophenyl)ethyl)cyclohexanone 

Relevant articles and documents

Structural tuning enables piezochromic and photochemical properties in N-aryl-β-enaminones

An efficient synthesis of N-aryl-β-enaminones via Et3N-mediated, one-pot three-component reaction of 4-hydroxycoumarin/dimedone, β-nitrostyrene/2-(2-nitrovinyl)thiophene, and arylamine in toluene under refluxed conditions is herein presented. Some prepared compounds were found to exhibit piezochromic properties. The XRD and SEM measurements of the piezochromic compound showed substantial crystal packing and morphology changes before and after grinding. Further, one prepared compound was found to be light-sensitive and can be converted to a furo[3,2-b]pyridin-2(4H)-one derivative upon UV irradiation. A plausible mechanism for this photochemical reaction was proposed.

TiO2-SO42- Catalyzed Synthesis and Antimicrobial Activity/Molecular Docking Studies of β-Indolylnitroalkanes

Michael addition of indole derivatives with various substituted nitrostyrenes to yield β- indolylnitroalkanes is accomplished effectively under solvent free conditions using TiO2-SO4 2- as efficient catalyst at 60 ° C. All the synthesized compounds were screened for their antibacterial activity through in silico and in vitro methods. The molecular docking studies against FabH enzyme, a potential drug target of bacterial fatty acid biosynthetic pathway indicated the scope of developing them a new class of antimicrobial agents. Among the title compounds, 5h exhibited the highest dock score and the highest antibacterial activity when compared with other compounds and the standard drug Ampicillin. In addition, the compounds 5d, 5e, 5g, 5h, 5i, 5j and 5l showed significant inhibitory activity at different dose concentrations under in vitro conditions against the specified bacterial strains thus qualifying for further clinical evaluation so that they can be used as effective anti-bacterial agents.

Mesoporous nickel hydroxyapatite nanocomposite for microwave-assisted Henry reaction

The utility of nickel hydroxyapatite nanocomposite (Ni-HAp) as a green catalyst for solvent free, microwave-assisted Henry reaction using nitromethane and a series of aromatic aldehydes as substrates is presented. The selected catalyst performed well to afford the respective nitrostyrenes which were quantified by gas chromatography equipped with a mass spectral detector (GC-MS). A few of the products were identified from the respective nuclear magnetic resonance (NMR) spectral data.