260443-93-4

Upstream product

• 260443-98-9 5,6-difluoro-2-(3-methyl-4-nitrophenyl)benzothiazole 
• 64695-79-0 2-bromo-4,5-difluoro-aniline 
• 35675-46-8 3-methyl-4-nitro-benzoyl chloride 
• 260444-04-0 N-(2-bromo-4,5-difluoro-phenyl)-3-methyl-4-nitro-thiobenzamide 
• 343975-62-2 N-(2-bromo-4,5-difluoro-phenyl)-3-methyl-4-nitro-benzamide 
• 343975-43-9 N-(3,4-difluoro-phenyl)-3-methyl-4-nitro-thiobenzamide 

Relevant academic research and scientific papers

Substituted 2-arylbenzazole compounds and their use as antitumour agents

Substituted 2-phenylbenzazole compounds of formula (I) wherein X represents S or O and Q represents a direct bond, —CH2— or —CH═Ch—, exhibt selective antiproliferactive activity in respect of mammalian tumour cells. At least in preferred enbodiments the b

Antitumor benzothiazoles. 14. Synthesis and in vitro biological properties of fluorinated 2-(4-aminophenyl)benzothiazoles

Synthetic routes to a series of mono- and difluorinated 2-(4-amino-3-substituted-phenyl)benzothiazoles have been devised. Whereas mixtures of regioisomeric 5- and 7-fluorobenzothiazoles were formed from the established Jacobsen cyclization of precursor 3-

The regiospecific synthesis of 5- and 7-monosubstituted and 5,6- disubstituted 2-arylbenzothiazoles

The regiospecific synthesis of a range of antitumour 2- arylbenzothiazoles substituted in the benzothiazole ring is described. In this procedure a bromine atom situated ortho to the anilido nitrogen is used to direct a regiospecific cyclisation where, in the absence of bromine, a mixture of regioisomers is produced. The chemistry described is applicable to the synthesis of 2-arylbenzothiazoles bearing both electron-withdrawing (- NO2) and electron-donating (-NH2) substituents on the aryl ring.