260443-98-9Relevant academic research and scientific papers
The regiospecific synthesis of 5- and 7-monosubstituted and 5,6- disubstituted 2-arylbenzothiazoles
Hutchinson, Ian,Stevens, Malcolm F. G.,Westwell, Andrew D.
, p. 425 - 428 (2000)
The regiospecific synthesis of a range of antitumour 2- arylbenzothiazoles substituted in the benzothiazole ring is described. In this procedure a bromine atom situated ortho to the anilido nitrogen is used to direct a regiospecific cyclisation where, in the absence of bromine, a mixture of regioisomers is produced. The chemistry described is applicable to the synthesis of 2-arylbenzothiazoles bearing both electron-withdrawing (- NO2) and electron-donating (-NH2) substituents on the aryl ring.
Antitumor benzothiazoles. 14. Synthesis and in vitro biological properties of fluorinated 2-(4-aminophenyl)benzothiazoles
Hutchinson,Chua,Browne,Trapani,Bradshaw,Westwell,Stevens
, p. 1446 - 1455 (2007/10/03)
Synthetic routes to a series of mono- and difluorinated 2-(4-amino-3-substituted-phenyl)benzothiazoles have been devised. Whereas mixtures of regioisomeric 5- and 7-fluorobenzothiazoles were formed from the established Jacobsen cyclization of precursor 3-
