26059-94-9

Upstream product

• 1022-45-3 2-phenyl-4(3H)-quinazolinone 
• 106-96-7 propargyl bromide 
• 118-92-3 anthranilic acid 
• 1022-46-4 2-phenyl-4H-3,1-benzoxazin-4-one 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1340670-97-4 4-(4-((2-phenylquinazolin-4-yloxy)methyl)-1,2,3-triazol-1-yl)butan-1-ol 
• 1213232-27-9 2-phenyl-4-((3-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)-3H-1,2,3-triazol-4-yl)methoxy)quinazoline 
• 1213232-26-8 2-phenyl-4-((1-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)-1H-1,2,3-triazol-4-yl)methoxy)quinazoline 
• 1213232-23-5 2-phenyl-4-((1-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-1H-1,2,3-triazol-4-yl)methoxy)quinazoline 
• 1213232-24-6 2-phenyl-4-((3-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-3H-1,2,3-triazol-4-yl)methoxy)quinazoline 

Relevant academic research and scientific papers

Synthesis of new 1,2,3-triazol-4-yl-quinazoline nucleoside and acyclonucleoside analogues

In this study, we describe the synthesis of 1,4-disustituted-1,2,3- triazoloquinazoline ribonucleosides or acyclonucleosides by means of 1,3-dipolar cycloaddition between various O or N-Alkylated propargyl-quinazoline and 1'-Azido-2',3',5'-tri-Obenzoylribose or activated alkylating agents under microwave conditions. None of the compounds selected showed significant anti-HCV activity in vitro.

Click chemistry: Studies on the synthesis of novel fluorous tagged triazol-4-yl substituted quinazoline derivatives and their biological evaluation - Theoretical and experimental validation

The formation of N- and O-propargylated quinazoline derivatives 2, 3 from quinazol-4-ones 1 was theoretically predicted by optimizations at B3LYP/6-31G* level, analysed kinetically and thermodynamically. Theoretical predictions are validated by experiment to observe the trends and found deviation. Thus, compound 1 was propargylated in basic media to obtain compound 2 and 3 in definite proportions. Each compound was further subjected to [3 + 2] cycloaddition using perfluoroalkyl azides through Click reaction under Sharpless conditions, and obtained a series of novel perfluoroalkyl-1H,1,2,3-triazol-4-yl substituted quinazolines 4, 5, and 6. All the compounds were screened for antimicrobial activity and identified potential compounds.

Synthesis and anticonvulsant activity of acetylenic quinazolinone derivatives

Acetylenic derivatives of quinazolinones and quinazolinediones were synthesized and evaluated for their anticonvulsant activity. Most compounds displayed seizure-antagonizing activity in the maximal electroshock test (MES test) in most cases associated wi