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26063-95-6

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26063-95-6 Usage

General Description

1-Isomangostin hydrate is a natural xanthone compound that is found in the stems of Garcinia mangostana. It possesses various biological activities, including anti-inflammatory, antioxidant, and anticancer properties. Studies have shown that 1-Isomangostin hydrate exhibits potential in preventing the proliferation of cancer cells and inducing apoptosis. Additionally, it has demonstrated the ability to inhibit the production of inflammatory mediators, making it a promising candidate for the treatment of inflammatory diseases. Its antioxidant properties also contribute to its potential therapeutic applications in combating oxidative stress-related conditions. Overall, 1-Isomangostin hydrate has shown promising pharmacological potential and warrants further research for its development in various medical and pharmaceutical applications.

Check Digit Verification of cas no

The CAS Registry Mumber 26063-95-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,0,6 and 3 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 26063-95:
(7*2)+(6*6)+(5*0)+(4*6)+(3*3)+(2*9)+(1*5)=106
106 % 10 = 6
So 26063-95-6 is a valid CAS Registry Number.

26063-95-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 5,9-Dihydroxy-11-(3-hydroxy-3-methylbutyl)-10-methoxy-2,2-dimethy l-3,4-dihydro-2H,12H-pyrano[2,3-a]xanthen-12-one

1.2 Other means of identification

Product number -
Other names 1-isomangostin hydrate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:26063-95-6 SDS

26063-95-6Downstream Products

26063-95-6Relevant articles and documents

Modified tetra-oxygenated xanthones analogues as anti-MRSA and P. aeruginosa agent and their synergism with vancomycin

Boonnak, Nawong,Chantrapromma, Suchada,Kaewpiboon, Chutima,Sathirakul, Korbtham

supporting information, (2020/08/21)

Five isolated xanthones from the C. cochinchinense and G. mangostana were evaluated and tested for antibacterial activities. Isolated 4 and 5 exhibited potent anti-MRSA and P. aeruginosa activity, but showed poor pharmacokinetic properties via ADMET prediction. It led us to improve pharmacokinetic properties of 4 and 5 by partially modifying them in acidic condition yielding fourteen analogues. It was found that analogues 4b, 4d and 5b possessed proper pharmacokinetic properties, while only 4b exhibited the best anti-MRSA and P. aeruginosa activity. The SEM results indicated that 4b may interact with or damage the cell wall of MRSA and P. aeruginosa. Moreover, a combination of 4b and vancomycin exhibits synergistic effect against both MRSA and P. aeruginosa at MIC value of 4.98 (MIC = 18.75 μg/mL for 4b) and 9.52 μg/mL (MIC = 75 μg/mL for 4b), respectively.

Chemistry of α-mangostin. Studies on the semisynthesis of minor xanthones from Garcinia mangostana

Morelli, Carlo F.,Biagiotti, Marco,Pappalardo, Valeria M.,Rabuffetti, Marco,Speranza, Giovanna

supporting information, p. 750 - 755 (2015/12/24)

α-Mangostin is the major prenylated xanthone from Garcinia mangostana and it has been used also in recent times as starting material for the semisynthetic preparation of various biologically active derivatives. Its structure is characterised by the presence of few functional groups amenable to chemical manipulations, but present in the molecule in multiple instances (three phenolic hydroxyl groups, two prenyl chains and two unsubstituted aromatic carbons). This study represents a first approach to the systematic investigation of the reactivity of α-mangostin and describes the semisynthesis of some minor xanthones isolated from G. mangostana.

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