26082-22-4

Usage

Uses

Used in Pharmaceutical Applications:
2-Adamantaneacetic acid is used as a building block in the synthesis of various pharmaceutical compounds due to its unique cage-like structure and chemical properties.
Used in Antiviral and Antibacterial Applications:
2-Adamantaneacetic acid is used as an antiviral and antibacterial agent, as it has been investigated for its potential to inhibit the replication of viruses and bacteria.
Used in Central Nervous System Applications:
2-Adamantaneacetic acid is used as a compound with biological activity in the central nervous system, as it has been studied for its potential effects on neurological processes.
Used in Drug Delivery Systems:
2-Adamantaneacetic acid is used as a component in drug delivery systems, as it has the ability to interact with cell membranes and penetrate into cells, enhancing the delivery and efficacy of therapeutic agents.
Used in Chemical Reactions:
2-Adamantaneacetic acid is used as a reagent in various chemical reactions, taking advantage of its unique structure and properties to facilitate the synthesis of other compounds.
Used in Materials Science:
2-Adamantaneacetic acid is used in the development of new materials, as its unique cage-like structure and chemical properties can contribute to the creation of innovative materials with specific characteristics.

Upstream product

• 38121-87-8 adamantan-2-ylacetonitrile 
• 75-35-4 1,1-Dichloroethylene 
• 41736-95-2 spiro[adamantane-2,3'-diazirine] 
• 25220-07-9 tricyclo<3.3.1.1^3,7>decylideneacetic acid 
• 700-58-3 2-Adamantanone 
• 59210-87-6 (2-Adamantyl)essigsaeure-ethylester 
• 25220-06-8 adamantan-2-ylidene-acetic acid ethyl ester 
• 38121-89-0 adamantan-2-ylideneacetonitrile 
• 32132-59-5 2-((1R,3R,5R,7R)-adamantan-2-yl)acetyl chloride 
• 29542-60-7 methyl 3-adamanthylpropanoate 
• 15897-81-1 adamantane-2-carboxylic acid 

Downstream Products

• 19026-73-4 1-adamantaneacetamide 

Relevant academic research and scientific papers

COMPOUNDS FOR TREATING RESPIRATORY DISEASE

Compounds of general formula (I) and their tautomeric forms all enantiomers and isotopic variants and salts and solvates thereof: Formula (I), wherein (AA) represents a single or a double bond and R1, R2, X1, X2, X3, X4, X5, Y and Z are as defined herein; are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A.

Polycyclic compound as well as pharmaceutical composition and application thereof

The invention discloses a polycyclic compound as well as a preparation method, a pharmaceutical composition and application thereof. The polycyclic compound (I), isomers, prodrugs, solvent compounds,hydrates, stable isotope derivatives or pharmaceutically

Discovery of adamantane based highly potent HDAC inhibitors

Herein, we report the development of highly potent HDAC inhibitors for the treatment of cancer. A series of adamantane and nor-adamantane based HDAC inhibitors were designed, synthesized and screened for the inhibitory activity of HDAC. A number of compounds exhibited GI50 of 10-100 nM in human HCT116, NCI-H460 and U251 cancer cells, in vitro. Compound 32 displays efficacy in human tumour animal xenograft model.

Adamantane-2-spiro-3'-diazirine in reactions with protic and aprotic acids

During the action of strong protic acids on adamantane-2-spiro-3'-diazirine addition of the proton is accompanied by the elimination of a molecule of nitrogen and the formation of the intermediate 2-adamantyl cation.In the presence of nucleophiles the latter is converted into the corresponding 2-substituted derivatives of adamantane.Lewis acids promote isomerization of the cyclic diazirine to the linear diazo compound, and the main reaction product is adamantanone azine.Trifluoroacetic acid and bromine react by both mechanisms simultaneously. (In the latter case Br+ plays the role of the proton in the first stage.)