260997-47-5Relevant articles and documents
Enantioselective and rapid Rh-catalyzed arylation of N -tosyl- and N -nosylaldimines in methanol
Chen, Chun-Chih,Gopula, Balraj,Syu, Jin-Fong,Pan, Jhih-Han,Kuo, Ting-Shen,Wu, Ping-Yu,Henschke, Julian P.,Wu, Hsyueh-Liang
, p. 8077 - 8085 (2015/03/18)
Enantiomerically enriched tosyl-protected diarylmethylamines were rapidly prepared by the asymmetric addition of arylboronic acids to N-tosylaldimines under mild conditions in the presence of a catalyst prepared in situ from Rh(I) and a chiral diene ligand. This methodology offers access to diarylmethylamines in good yields with excellent chiral purity at room temperature using MeOH as a solvent and NEt3 as a base. Its synthetic utility was demonstrated by the preparation of (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline (14), an antagonist of the N-methyl-d-aspartate (NMDA) receptor.
Electronic and steric tuning of chiral diene ligands for rhodium-catalyzed asymmetric arylation of imines
Okamoto, Kazuhiro,Hayashi, Tamio,Rawal, Viresh H.
supporting information; experimental part, p. 4815 - 4817 (2009/12/08)
Rhodium-catalyzed asymmetric arylation of imines using electronically and sterically-modified chiral diene ligands gave the corresponding diarylmethylamines in high yield and with high enantioselectivity using just 0.3 mol% of catalyst.
Rhodium-catalyzed asymmetric arylation of imines with organostannanes. Asymmetric synthesis of diarylmethylamines [14]
Hayashi, Tamio,Ishigedani, Mitsuo
, p. 976 - 977 (2007/10/03)
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