260998-52-5

Basic information

• Product Name: (S)-1-Phenyl-N-[(S)-1-phenylbutoxy]pentylamine
• Synonyms: (S)-1-Phenyl-N-[(S)-1-phenylbutoxy]pentylamine
• CAS NO: 260998-52-5
• Molecular Weight: 311.467
• Mol File: 260998-52-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-1-Phenyl-N-[(S)-1-phenylbutoxy]pentylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-Phenyl-N-[(S)-1-phenylbutoxy]pentylamine(260998-52-5)
• EPA Substance Registry System: (S)-1-Phenyl-N-[(S)-1-phenylbutoxy]pentylamine(260998-52-5)

Safety Data

• Hazardous Substances Data: 260998-52-5(Hazardous Substances Data)

Upstream product

• 109-72-8 n-butyllithium 
• 260998-33-2 (E)-(S)-(-)-O-(1-phenylbutyl) benzaldehyde oxime 
• 100-52-7 benzaldehyde 
• 185758-21-8 (S)-(-)-N-(1-phenylbutoxy)phthalimide 

Downstream Products

• 105370-60-3 (1S)-1-amino-1-phenylpentane 

Relevant articles and documents

Chiral oxime ethers in asymmetric synthesis. Part 4. Asymmetric synthesis of N-protected amines and β-amino acids by the addition of organometallic reagents to ROPHy/SOPHy-derived aldoximes

Addition of organolithium or Grignard reagents to (R)- or (S)-O-(1-phenylbutyl)aldehyde oximes 1 in the presence of boron trifluoride-diethyl ether results in the formation of hydroxylamines 2 in good to excellent diastereoselectivity. Subsequent cleavage of the N-O bond with zinc-acetic acid-ultrasound, and carbamate formation, gives N-protected amines 3 in good enantiomeric purity (77-100% ee). When allylmagnesium bromide was used as the organometallic reagent, the resulting hydroxylamines were converted into β-amino acid derivatives 4 and γ-aminb alcohols 5. The Royal Society of Chemistry 1999.