2613-33-4

Basic information

• Product Name: 4-CHLORO-3,5-DIFLUORO-PHENYLAMINE
• Synonyms: 4-CHLORO-3,5-DIFLUORO-PHENYLAMINE;4-Chloro-3,5-difluoroaniline
• CAS NO: 2613-33-4
• Molecular Formula: C₆H₄ClF₂N
• Molecular Weight: 163.5524664
• Mol File: 2613-33-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 78-79 °C(Solv: ethanol (64-17-5))
• Boiling Point: 236.2±35.0 °C(Predicted)
• Appearance: /
• Density: 1.459±0.06 g/cm3(Predicted)
• Storage Temp.: Room temperature.
• PKA: 1.93±0.10(Predicted)
• CAS DataBase Reference: 4-CHLORO-3,5-DIFLUORO-PHENYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-3,5-DIFLUORO-PHENYLAMINE(2613-33-4)
• EPA Substance Registry System: 4-CHLORO-3,5-DIFLUORO-PHENYLAMINE(2613-33-4)

Safety Data

• Hazardous Substances Data: 2613-33-4(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 23, p. 1612, 1958 DOI: 10.1021/jo01105a006

Upstream product

• 2106-40-3 2-chloro-1,3,5-trifluorobenzene 
• 372-39-4 3,5-difluoroaniline 
• 106-47-8 4-chloro-aniline 
• 3828-41-9 2-chloro-1,3-difluoro-5-nitrobenzene 

Downstream Products

• 1622209-17-9 N-(4-chloro-3,5-difluorophenyl)-3-nitropyridin-2-amine 
• 1622209-18-0 N²-(4-chloro-3,5-difluorophenyl)pyridine-2,3-diamine 
• 1979-25-5 2-(4-chloro-3,5-difluorophenoxy)acetic acid 
• 2268-03-3 4-chloro-3,5-difluoro-phenol 

Relevant articles and documents

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SULPHONAMIDES AND COMPOSITIONS THEREOF FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY

In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: wherein the variables shown in Formula AA can be as defined anywhere herein. Compounds AA are modulators of NLRP1 and/or NLRP3

Electrophilic aromatic fluorination with fluorine: meta-Directed fluorination of anilines

Anilines are mainly or selectively fluorinated in the meta-position with F2 when dissolved in triflic acid, sometimes in the presence of small quantities of antimony pentafluoride. The regioselectivity is increased when an electron-donating substituent is present at the para-position.