26131-22-6

Upstream product

• 13431-34-0 N-ethylthiosemicarbazide 
• 122-01-0 4-chloro-benzoyl chloride 
• 542-85-8 Ethyl isothiocyanate 
• 536-40-3 4-chlorobenzoic acid hydrazide 
• 74-11-3 para-chlorobenzoic acid 
• 7335-27-5 ethyl 4-chlorobenzoate 

Downstream Products

• 35317-61-4 [5-(4-chloro-phenyl)-[1,3,4]thiadiazol-2-yl]-ethyl-amine 
• 26131-64-6 5-(4-chlorophenyl)-4-ethyl-1,2,4-triazole-3-thiol 
• 26131-64-6 5-(4-Chloro-phenyl)-4-ethyl-2,4-dihydro-[1,2,4]triazole-3-thione 
• 150535-90-3 2-[5-(4-Chloro-phenyl)-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanyl]-propionic acid methyl ester 
• 150536-02-0 2-[5-(4-Chloro-phenyl)-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanyl]-propionic acid 
• 150535-89-0 [5-(4-Chloro-phenyl)-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanyl]-acetic acid methyl ester 
• 150536-01-9 [5-(4-Chloro-phenyl)-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanyl]-acetic acid 
• 31409-18-4 3-(4-chloro-phenyl)-4-ethyl-5-methylsulfanyl-4H-[1,2,4]triazole 

Relevant academic research and scientific papers

Design, synthesis and molecular docking of new N-4-piperazinyl ciprofloxacin-triazole hybrids with potential antimicrobial activity

New N-4-piperazinyl ciprofloxacin-triazole hybrids 6a-o were prepared and characterized. The in vitro antimycobacterial activity revealed that compound 6a experienced promising antimycobacterial activity against Mycobactrium smegmatis compared with the reference isoniazide (INH). Additionally, compound 6a exhibited broad spectrum antibacterial activity against all the tested strains either Gram-positive or Gram-negative bacteria compared with the reference ciprofloxacin. Also, compounds 6g and 6i displayed considerable antifungal activity compared with the reference ketoconazole. DNA cleavage assay of the highly active compounds 6c and 6h showed a good correlation between the Mycobactrium cleaved DNA gyrase assay and their in vitro antimycobactrial activity. Moreover, molecular modeling studies were done for the designed ciprofloxacin derivatives to predict their binding modes towards Topoisomerase II enzyme (PDB: 5bs8).

5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents

Selected examples from three series of isomeric (alkylthio)-1,2,4- triazoles were prepared and examined for anticonvulsant activity versus strychnine-, maximal-electroshock-, pentylenetetrazole-, and 3- mercaptopropionic-acid-induced seizures in mice. A n