261363-01-3Relevant articles and documents
Synthesis and antimycobacterial activity of some isonicotinoylhydrazones
Cocco, Maria T.,Congiu, Cenzo,Onnis, Valentina,Pusceddu, Maria C.,Schivo, Maria L.,De Logu, Alessandro
, p. 1071 - 1076 (2007/10/03)
A series of isonicotinoylhydrazones 2 were prepared by addition of some aryloxyacetonitriles with isonicotinoylhydrazine in basic medium. These compounds have been further reacted with pyridinecarboxaldehydes to give the corresponding pyridylmethyleneamino derivatives 3-5. The new synthesized hydrazones and their pyridylmethyleneamino derivatives were tested for their activity against mycobacteria, Gram-positive and Gram-negative bacteria. The cytotoxicity was also tested. Several compounds showed a good activity against Mycobacterium tuberculosis H37Rv and some isonycotinoylhydrazones 2 showed a moderate activity against a clinically isolated M. tuberculosis which was isoniazid resistant.