26146-71-4Relevant articles and documents
Selenoacyclovir and Selenoganciclovir: Discovery of a New Template for Antiviral Agents
Sahu, Pramod K.,Umme, Tamima,Yu, Jinha,Nayak, Akshata,Kim, Gyudong,Noh, Minsoo,Lee, Jae-Young,Kim, Dae-Duk,Jeong, Lak Shin
, p. 8734 - 8738 (2015)
On the basis of the potent antiviral activity of acyclovir and ganciclovir, selenoacyclovir (2a) and selenoganciclovir (2b) were designed based on bioisoteric rationale and synthesized via the diselenide 7 as the key intermediate. Compound 2a exhibited potent anti-HSV-1 and -2 activities while 2b exerted moderate anti-HCMV activity, indicating that these nucleosides can serve as a novel template for the development of new antiviral agents.