26166-62-1Relevant academic research and scientific papers
Gem-Dinitroalkyl Benzenes: A Novel Class of IOP-Lowering Agents for the Treatment of Ocular Hypertension
Blangetti, Marco,Rolando, Barbara,Marini, Elisabetta,Chegaev, Konstantin,Guglielmo, Stefano,Lazzarato, Loretta,Lucarini, Laura,Masini, Emanuela,Fruttero, Roberta
, p. 1054 - 1059 (2017)
Primary open angle glaucoma is the second most common cause of blindness worldwide. Nitric oxide has recently received particular attention as a potential antiglaucoma agent. In this work, gem-dinitroalkyl benzenes are evaluated for their capability to ac
Synthesis and Properties of Dinitromethylated Arenes. Reinvestigation of the Ponzio Reaction
Suzuku, Hitomi,Takaoka, Hiroshi,Yamamoto, Hidetoshi,Ogawa, Takuji
, p. 2927 - 2932 (2007/10/02)
Several title compounds have been prepared by the modified Ponzio procedure and their IR, 1 H and 13 C NMR data are presented.In some cases trinitromethylated arenes were obtained as a by-product.Oxidative cleavage to parent aldehydes and oxidation to carboxylic acids were the major competing reactions. 9-Anthracenecarbaldehyde oxime and 10-methyl-9-anthracenecarbaldehyde oxime reacted with nitrogen dioxide in an unexpected way, giving 10-nitro-9-anthracenecarbonitrile oxide and 10-methyl-10-nitro-9-anthrone as the respective main products.Nitration of (dinitromethyl)benzene has also been examined under various conditions.
